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HODHBt

Cat. No. 6994 Submit a Review Datasheet / COA / SDS

Discontinued Product

6994 has been discontinued.

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Description: STAT5-SUMO protein-protein interaction inhibitor
Chemical Name: 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for HODHBt

HODHBt is a STAT5-SUMO protein-protein interaction inhibitor. Blocks SUMOylation of phosphorylated STAT5. Reactivates latent HIV-1 reservoir in central memory T cells (TCM). Increases viral release by ~2.7-fold at a concentration of 100 μM in combination with IL-2 compared to unstimulated cells; reduces size of latent HIV-1 reservoir in vitro.

Technical Data for HODHBt

M. Wt 163.14
Formula C7H5N3O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 28230-32-2
PubChem ID 73026
InChI Key HJBLUNHMOKFZQX-UHFFFAOYSA-N
Smiles ON1N=NC2=CC=CC=C2C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for HODHBt

References are publications that support the biological activity of the product.

Bosque et al (2017) Benzotriazoles reactivate latent HIV-1 through inactivation of STAT5 SUMOylation. Cell Rep. 18 1324 PMID: 28147284

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Keywords: HODHBt, HODHBt supplier, STAT5, SUMO, SUMOylation, protein-protein, interactions, inhibitors, inhibits, HIV-1, reservoir, STAT, HIV, 6994, Tocris Bioscience

Citations for HODHBt

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Pathways for HODHBt

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.