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iMAC2

Cat. No. 3794 Submit a Review Datasheet / COA / SDS

Discontinued Product

3794 has been discontinued.

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Description: Suppressor of mitochondrial apoptosis
Chemical Name: 3,6-Dibromo-9-[2-fluoro-3-(1-piperazinyl)propyl]-9H-carbazole dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for iMAC2

iMAC2 is an inhibitor of mitochondrial apoptosis-induced channel (MAC) (IC50 = 28 nM). Reduces STS-induced apoptosis in FL5.12 cells by over 50%. Inhibits release of cytochrome c by Bid-induced Bax activation (IC50 = 0.68 μM).

Technical Data for iMAC2

M. Wt 542.11
Formula C19H20Br2FN3.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 335166-00-2
PubChem ID 90488878
InChI Key JWCVUOLQOHIRML-UHFFFAOYSA-N
Smiles BrC(C=C3)=CC1=C3N(CC(F)CN4CCNCC4)C2=C1C=C(Br)C=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for iMAC2

References are publications that support the biological activity of the product.

Bombrun et al (2003) 3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J.Med.Chem. 46 4365 PMID: 14521400

Peixoto et al (2009) MAC inhibitors suppress mitochondrial apoptosis. Biochem.J. 423 381 PMID: 19691447

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Citations for iMAC2

Citations are publications that use Tocris products.

Currently there are no citations for iMAC2.

Reviews for iMAC2

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for iMAC2

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.