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Submit ReviewIsoginkgetin
Description: Pre-mRNA splicing inhibitor; cell permeable
Chemical Name: 8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Biological Activity for Isoginkgetin
Isoginkgetin is a pre-mRNA splicing inhibitor (IC50 ~ 30 μM); inhibits major and minor spliceosomes. Suppresses transcriptional elongation. Blocks spliceosome-mediated splicing process at the pre-spliceosome/A complex stage. Does not inhibit CDK9. Inhibits tumor cell invasion. Active in vivo. Cell permeable
Technical Data for Isoginkgetin
| M. Wt | 566.51 |
| Formula | C32H22O10 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 548-19-6 |
| PubChem ID | 5318569 |
| InChI Key | HUOOMAOYXQFIDQ-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(C2=CC(C3=C(C=C(C(C4=CC(C5=CC(C6=C(C=C(C=C6O5)O)O)=O)=CC=C4OC)=C3O2)O)O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Isoginkgetin
References for Isoginkgetin
References are publications that support the biological activity of the product.
O'Brien et al (2008) The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing. J.Biol.Chem. 283 33147 PMID: 18826947
Szewczak et al (2017) The right tool for the job. Cell 169 561 PMID: 28475886
Boswell et al (2017) Total RNA-seq to identify pharmacological effects on specific stages of mRNA synthesis. Nat.Chem.Biol. 13 501 PMID: 28263964
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Keywords: Isoginkgetin, Isoginkgetin supplier, mRNA, splicing, inhibitors, inhibits, cell-permeable, spliceosomes, transcriptional, elongation, DNA,, RNA, and, Protein, Synthesis, 6483, Tocris Bioscience
1 Citation for Isoginkgetin
Citations are publications that use Tocris products. Selected citations for Isoginkgetin include:
Sharon A et al (2021) Alternative splicing is a developmental switch for hTERT expression. Mol Cell 81 2349-2360.e6 PMID: 33852895
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Literature in this Area
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