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K 22

Cat. No. 7338 Submit a Review Datasheet / COA / SDS
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Description: Inhibits coronavirus RNA replication; impairs double membrane vesicle (DMV) formation
Chemical Name: N-[(1Z)-1-[[4-(4-Bromophenyl)-4-hydroxy-1-piperidinyl]carbonyl]-2-phenylethenyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
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Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for K 22

K 22 is a viral RNA synthesis inhibitor; targets membrane-bound coronaviral RNA replication by inhibiting double membrane vesicle (DMV) formation. Inhibits HCoV-229E infection of MRC-5 cells in a plaque forming assay (IC50 = 0.7 μM). Also inhibits HCoV-229E and MERS-CoV replication in human airway epithelia cultures.

Technical Data for K 22

M. Wt 505.41
Formula C27H25BrN2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2141978-86-9
PubChem ID 5433970
InChI Key CMBUSPXASRNJHI-CLCOLTQESA-N
Smiles OC1(C2=CC=C(Br)C=C2)CCN(C(/C(=C/C3=CC=CC=C3)/NC(=O)C4=CC=CC=C4)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for K 22

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.54 100

Preparing Stock Solutions for K 22

The following data is based on the product molecular weight 505.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.98 mL 9.89 mL 19.79 mL
5 mM 0.4 mL 1.98 mL 3.96 mL
10 mM 0.2 mL 0.99 mL 1.98 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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References for K 22

References are publications that support the biological activity of the product.

Lundin et al (2014) Targeting membrane-bound viral RNA synthesis reveals potent inhibition of diverse coronaviruses including the middle East respiratory syndrome virus. PLoS Pathog. 10 e1004166 PMID: 24874215

If you know of a relevant reference for K 22, please let us know.

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Citations for K 22

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Literature in this Area

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