Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMG 101
Description: Calpain inhibitor; activates p53-dependent apoptosis
Alternative Names: Calpain inhibitor-1
Chemical Name: N-Acetyl-L-leucine-L-leucine-L-norleucinal
Biological Activity for MG 101
Calpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines. Increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro. Also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of iNOS and COX-2 expression.
Technical Data for MG 101
| M. Wt | 383.53 |
| Formula | C20H37N3O4 |
| Storage | Store at -20°C |
| CAS Number | 110044-82-1 |
| PubChem ID | 443118 |
| InChI Key | FMYKJLXRRQTBOR-BZSNNMDCSA-N |
| Smiles | CCCC[C@H](NC([C@@H](N[C@@]([C@H](CC(C)C)NC(C)=O)=O)CC(C)C)=O)C=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MG 101
References for MG 101
References are publications that support the biological activity of the product.
Atencio et al (2000) Calpain inhibitor 1 activates p53-dependent apoptosis in tumor cell lines. Cell Growth Differ. 11 247 PMID: 10845425
Chatterjee et al (2001) Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat. Kidney Int. 59 2073 PMID: 11380809
Sherwood et al (1993) In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal. Proc.Natl.Acad.Sci.USA 90 3353
Perrin et al (2002) In vitro antioxidant properties of calpain inhibitors: leupeptin and calpain inhibitor-1. Cell Mol.Biol. 48 OL267
View Related Products by Target
View Related Products by Product Action
Keywords: MG 101, MG 101 supplier, Calpain, inhibitors, inhibits, Proteinases, Proteases, MG101, inhibitor-1, Calpains, Calcium-Sensitive, 3358, Tocris Bioscience
1 Citation for MG 101
Citations are publications that use Tocris products. Selected citations for MG 101 include:
Ishizuka et al (2016) PAFR activation of NF-& #954;B p65 or p105 precursor dictates pro-and anti-inflammatory responses during TLR activation in murine macrophages Scientific Reports 6 32092 PMID: 27554194
Reviews for MG 101
There are currently no reviews for this product. Be the first to review MG 101 and earn rewards!
Have you used MG 101?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Pathways for MG 101
