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Description: MALT1 inhibitor
Chemical Name: 2-Chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenylacetamide
Purity: ≥98% (HPLC)
Biological Activity for MI 2 (MALT1 inhibitor)
MI 2 (MALT1 inhibitor) is a MALT1 inhibitor (IC50 = 5.84 μM). Binds directly to MALT1 and irreversibly suppresses protease function. Decreases NF-κB activity induced by MALT1. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) tumor xenografts in mice and primary human ABC-DLBCLs ex vivo.
Technical Data for MI 2 (MALT1 inhibitor)
| M. Wt | 455.72 |
| Formula | C19H17Cl3N4O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1047953-91-2 |
| PubChem ID | 45942672 |
| InChI Key | TWJGQZBSEMDPQP-UHFFFAOYSA-N |
| Smiles | O=C(CCl)NC(C=C3)=CC=C3N1C(C2=CC(Cl)=C(Cl)C=C2)=NC(OCCOC)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MI 2 (MALT1 inhibitor)
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.57 | 100 | |
| ethanol | 9.11 | 20 |
Preparing Stock Solutions for MI 2 (MALT1 inhibitor)
The following data is based on the product molecular weight 455.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.19 mL | 10.97 mL | 21.94 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.39 mL |
| 10 mM | 0.22 mL | 1.1 mL | 2.19 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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Product Datasheets for MI 2 (MALT1 inhibitor)
References for MI 2 (MALT1 inhibitor)
References are publications that support the biological activity of the product.
Fontan et al (2012) MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell 22 812 PMID: 23238016
If you know of a relevant reference for MI 2 (MALT1 inhibitor), please let us know.
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Keywords: MI 2 (MALT1 inhibitor), MI 2 (MALT1 inhibitor) supplier, MI2, MALT, 1, inhibitors, inhibits, NF-KB, NFKB, NF, Kappa, B, NFκB, lymphoma, ABC-DLBCL, Other, Proteases, 4848, Tocris Bioscience
Citations for MI 2 (MALT1 inhibitor)
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Reviews for MI 2 (MALT1 inhibitor)
Average Rating: 5 (Based on 1 Review.)
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A MALT1 Protease Inhibitor that works really well.
By
Anonymous on 12/08/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: MDA231, U2OS
MALT1 protease inhibitor MI-2 suppress RelB cleavage in a dose-dependent manner in U2OS osteosarcoma cells. Cells were pretreated with increasing concentration of MI2 inhibitor (0.25, 0.5, 1, or 2 µM) for 1 h prior to stimulation with 2 U/mL thrombin for an additional 3 h. MDA-MB-231 cells stimulated with thrombin also show evidence of RelB cleavage that is suppressed by MI-2 (2 μM).
