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Description: HIF pathway activator
Chemical Name: N-([1,1'Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine
Purity: ≥98% (HPLC)
Biological Activity for ML 228
ML 228 is a HIF pathway activator (EC50 values are 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of iron, independently of PHD. Also exhibits > 80% inhibition of the human A3 receptor, dopamine transporter, μ receptor, hERG and 5-HT2B receptor, and rat sodium channel site 2, at a concentration of 10 μM.
Compound Libraries for ML 228
ML 228 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
Technical Data for ML 228
| M. Wt | 415.49 |
| Formula | C27H21N5 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1357171-62-0 |
| PubChem ID | 46742353 |
| InChI Key | QNRODODTMXCRKU-UHFFFAOYSA-N |
| Smiles | C1(C2=NC(NCC4=CC=C(C5=CC=CC=C5)C=C4)=C(C3=CC=CC=C3)N=N2)=NC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ML 228
References for ML 228
References are publications that support the biological activity of the product.
Theriault et al (2012) Discovery of a new molecular probe ML228: an activator of the hypoxia inducible factor (HIF) pathway. Bioorg.Med.Chem.Lett. 22 76 PMID: 22172704
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Keywords: ML 228, ML 228 supplier, ML228, hypoxia, inducible, factor, HIF, pathway, activators, iron, chelators, HRE, Hypoxia, Inducible, Factors, 4565, Tocris Bioscience
Citations for ML 228
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Currently there are no citations for ML 228.
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