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Submit ReviewML 240
Description: ATP-competitive inhibitor of p97 ATPase
Chemical Name: 2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine
Purity: ≥99% (HPLC)
Biological Activity for ML 240
ML 240 is an ATP-competitive inhibitor of p97 ATPase (VCP, IC50 = 110 nM). Exhibits antiproliferative activity in NCI-60 cancer cell lines and rapidly induces executioner caspases 3 and 7 in multiple colon cancer cells. Promotes accumulation of LC3-II and impairs autophagosome maturation. Also impairs the endoplasmic-reticulum-associated degradation (ERAD) pathway.
Compound Libraries for ML 240
ML 240 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for ML 240
| M. Wt | 396.44 |
| Formula | C23H20N6O |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1346527-98-7 |
| PubChem ID | 49830258 |
| InChI Key | NHAMBLRUUJAFOY-UHFFFAOYSA-N |
| Smiles | NC1=NC4=C(C=CC=C4)N1C3=NC2=C(OC)C=CC=C2C(NCC5=CC=CC=C5)=N3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ML 240
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.93 | 20 |
Preparing Stock Solutions for ML 240
The following data is based on the product molecular weight 396.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.61 mL | 63.06 mL | 126.12 mL |
| 1 mM | 2.52 mL | 12.61 mL | 25.22 mL |
| 2 mM | 1.26 mL | 6.31 mL | 12.61 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.52 mL |
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Product Datasheets for ML 240
References for ML 240
References are publications that support the biological activity of the product.
Chou et al (2013) Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase. ChemMedChem 8 297 PMID: 23316025
If you know of a relevant reference for ML 240, please let us know.
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Keywords: ML 240, ML 240 supplier, ML240, ATP, competitive, inhibitors, AAA, ATPases, p97, VCP, valosin, autophagy, inhibits, Autophagy, Other, ER, stress/UPR, ATPase, Translocation, 5153, Tocris Bioscience
Citations for ML 240
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