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Submit ReviewMOG (35-55)
Description: Encephalitogenic myelin oligodendrocyte glycoprotein fragment
Purity: ≥95% (HPLC)
Biological Activity for MOG (35-55)
MOG (35-55) or myelin oligodendrocyte glycoprotein (MOG) 35-55 is a minor component of CNS myelin. MOG (35-55) produces a relapsing-remitting neurological disease with extensive plaque-like demyelination, common to the manifestations of multiple sclerosis. MOG (35-55) induces strong T and B cell responses and is highly encephalitogenic. MOG (35-55) induces T cell-mediated multiple sclerosis in animal models. When co-administered with ITE, MOG (35-55) induces tolerogenic dendritic cells and suppresses disease development in mouse preclinical models of multiple sclerosis.
Technical Data for MOG (35-55)
| M. Wt | 2581.97 |
| Formula | C118H177N35O29S |
| Sequence | MEVGWYRSPFSRVVHLYRNGK |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 149635-73-4 |
| PubChem ID | 24868190 |
| InChI Key | JMTCEFUSRHYJBF-DDJPMISGSA-N |
| Smiles | [H]N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MOG (35-55)
| Solubility | Soluble to 0.50 mg/ml in water |
Product Datasheets for MOG (35-55)
References for MOG (35-55)
References are publications that support the biological activity of the product.
Ichikawa et al (1996) Analysis of the fine B cell specificity during the chronic/relapsing course of a multiple sclerosis-like disease in Lewis rats injected with the encephalitogenic myelin oligodendrocyte glycoprotein peptide 35-55. J.Immunol. 157 919 PMID: 8752946
Slavin et al (1998) Induction of a multiple sclerosis-like disease in mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein. Autoimmunity 28 109 PMID: 9771980
Zhang et al (2004) T cell and antibody responses in remitting-relapsing experimental autoimmune encephalomyelitis in (C57BL/6xSJL) F1 mice. J.Neuroimmunol. 148 1 PMID: 14975581
Kenison et al (2020) Tolerogenic nanoparticles suppress central nervous system inflammation. Proc.Natl.Acad.Sci.U.S.A. 117 32017 PMID: 33239445
Miyamura et al (2019) Myelin oligodendrocyte glycoprotein 35-55 (MOG 35-55)-induced experimental autoimmune encephalomyelitis: a model of chronic multiple sclerosis. Bio.Protoc. 9 e3453 PMID: 33654948
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Keywords: MOG (35-55), MOG (35-55) supplier, Encephalitogenic, myelin, oligodendrocyte, glycoprotein, fragment, Neuronal, Metabolism, 2568, Tocris Bioscience
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