Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewNCT 02
Description: Molecular glue; induces degradation of CCNK and CDK12
Chemical Name: 6,7-Dihydro-N-(5-methyl-2-thiazolyl)-5H-indeno[5,6-b]furan-3-acetamide
Purity: ≥98% (HPLC)
Biological Activity for NCT 02
NCT 02 acts as a molecular glue that induces proteasomal degradation of CCNK and CDK12 in colorectal cancer spheroid cells in vitro (IC50 ≤ 50 μM). NCT 02 also induces apoptosis and the downregulation of genes involved in DNA damage repair.
Technical Data for NCT 02
| M. Wt | 312.39 |
| Formula | C17H16N2O2S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 790245-61-3 |
| PubChem ID | 2501755 |
| InChI Key | IELCYEUTXLYDOV-UHFFFAOYSA-N |
| Smiles | CC1=CN=C(S1)NC(CC2=COC3=C2C=C4CCCC4=C3)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NCT 02
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.24 | 100 |
Preparing Stock Solutions for NCT 02
The following data is based on the product molecular weight 312.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.2 mL | 16.01 mL | 32.01 mL |
| 5 mM | 0.64 mL | 3.2 mL | 6.4 mL |
| 10 mM | 0.32 mL | 1.6 mL | 3.2 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for NCT 02
References for NCT 02
References are publications that support the biological activity of the product.
Dieter et al (2021) Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer. Cell Rep. 36 109394 PMID: 34289372
If you know of a relevant reference for NCT 02, please let us know.
View Related Products by Target
Keywords: NCT 02, NCT 02 supplier, NCT02, molecular, glue, proteasomal, degraders, inhibitors, inhibit, inhibition, apoptosis, ubiquitination, CCNK, cyclin, K, CDK12, Molecular, Glues, Transcriptional, CDKs, 7551, Tocris Bioscience
Citations for NCT 02
Citations are publications that use Tocris products.
Currently there are no citations for NCT 02. Do you know of a great paper that uses NCT 02 from Tocris? Please let us know.
Reviews for NCT 02
There are currently no reviews for this product. Be the first to review NCT 02 and earn rewards!
Have you used NCT 02?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
TPD and Induced Proximity Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Assays for Protein Degradation
- Induced Proximity Tools