Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewNICE 01
Description: Heterobifunctional compound for nuclear import of FKBPF36V tagged proteins
Chemical Name: (R)-1-(3-((14-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2,13-dioxo-6,9-dioxa-3,12-diazatetradecyl)oxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity: ≥98% (HPLC)
Biological Activity for NICE 01
NICE 01 is a bifunctional molecule consisting of (+)-JQ1 (Cat. No. 4499) and AP 1867 (Cat. No. 6207), with a PEG2-diamine linker. It has a high affinity (Kd = 94 pM) for FKBPF36V tagged proteins. It can induce nuclear localization of cytosolic proteins and target transcriptional regulation. It can be used to calculate the kinetic constant and passive diffusion across the nuclear pore.
Technical Data for NICE 01
| M. Wt | 1206.85 |
| Formula | C63H76ClN7O13S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2982819-94-1 |
| PubChem ID | 169183208 |
| InChI Key | USCBOLCYUGPYAF-YUZLDYPQSA-N |
| Smiles | O=C(O[C@H](CCC1=CC=C(C(OC)=C1)OC)C2=CC=CC(OCC(NCCOCCOCCNC(C[C@H]3C4=NN=C(N4C5=C(C(C6=CC=C(C=C6)Cl)=N3)C(C)=C(S5)C)C)=O)=O)=C2)[C@H]7N(CCCC7)C([C@@H](CC)C8=CC(OC)=C(C(OC)=C8)OC)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NICE 01
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 60.34 | 50 |
Preparing Stock Solutions for NICE 01
The following data is based on the product molecular weight 1206.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 1.66 mL | 8.29 mL | 16.57 mL |
| 2.5 mM | 0.33 mL | 1.66 mL | 3.31 mL |
| 5 mM | 0.17 mL | 0.83 mL | 1.66 mL |
| 25 mM | 0.03 mL | 0.17 mL | 0.33 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for NICE 01
References for NICE 01
References are publications that support the biological activity of the product.
Lu et al (2022) Bioorthogonal chemical epigenetic modifiers enable dose-dependent CRISPR targeted gene activation in mammalian cells. A.C.S.Synth.Biol. 11 1397 PMID: 35302756
Gibson et al (2023) Bifunctional small molecules that induce nuclear localization and targeted transcriptional regulation. J.Am.Chem.Soc. 145 26028 PMID: 37461636
If you know of a relevant reference for NICE 01, please let us know.
View Related Products by Target
Keywords: NICE 01, NICE 01 supplier, CEM207, FKBPF36V, tagged, proteins, BRD4, FKBP, NICE-01, NICE01, Protein, Dimerizers, 8088, Tocris Bioscience
Citations for NICE 01
Citations are publications that use Tocris products.
Currently there are no citations for NICE 01. Do you know of a great paper that uses NICE 01 from Tocris? Please let us know.
Reviews for NICE 01
There are currently no reviews for this product. Be the first to review NICE 01 and earn rewards!
Have you used NICE 01?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image