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NSC 74859

Cat. No. 4655 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective STAT3 inhibitor
Alternative Names: S3I-201
Chemical Name: 2-Hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for NSC 74859

NSC 74859 selectively inhibits STAT3 DNA-binding activity in vitro (IC50 values are 86, 160, and >300 μM for STAT3-STAT3, STAT1-STAT3 and STAT1-STAT1 DNA-binding activity respectively). NSC 74859 blocks growth and induces apoptosis preferentially in tumor cells that contain persistently active STAT3 in vitro and arrests tumor growth in a murine xenograft model in vivo.

Compound Libraries for NSC 74859

NSC 74859 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for NSC 74859

M. Wt 365.36
Formula C16H15NO7S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 501919-59-1
PubChem ID 252682
InChI Key HWNUSGNZBAISFM-UHFFFAOYSA-N
Smiles CC1=CC=C(S(OCC(NC2=CC=C(C(O)=O)C(O)=C2)=O)(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NSC 74859

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.54 100

Preparing Stock Solutions for NSC 74859

The following data is based on the product molecular weight 365.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.69 mL 27.37 mL
5 mM 0.55 mL 2.74 mL 5.47 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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References for NSC 74859

References are publications that support the biological activity of the product.

Lin et al (2009) The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene 28 961 PMID: 19137011

Siddiquee et al (2007) Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc.Natl.Acad.Sci.U.S.A. 104 7391 PMID: 17463090

If you know of a relevant reference for NSC 74859, please let us know.

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Keywords: NSC 74859, NSC 74859 supplier, NSC74859, STAT3, inhibitors, inhibits, DNA-binding, apoptosis, S3I-201, STAT, 4655, Tocris Bioscience

2 Citations for NSC 74859

Citations are publications that use Tocris products. Selected citations for NSC 74859 include:

Yuan-Soon et al (2019) The α9 Nicotinic Acetylcholine Receptor Mediates Nicotine-Induced PD-L1 Expression and Regulates Melanoma Cell Proliferation and Migration. Cancers (Basel) 11 PMID: 31835799

Edmund C et al (2020) Local and Systemic STAT3 and p65 NF-KappaB Expression as Progression Markers and Functional Targets for Patients With Cervical Cancer. Front Oncol 10 587132 PMID: 33330068

Do you know of a great paper that uses NSC 74859 from Tocris? Please let us know.

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Pathways for NSC 74859

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.