Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewONO 2506
Description: Inhibits S-100β synthesis; neuroprotective
Alternative Names: Arundic acid
Chemical Name: (2R)-2-Propyloctanoic acid
Biological Activity for ONO 2506
ONO 2506 inhibits S-100β synthesis in activated cultured astrocytes. Prevents delayed infarct expansion 24 hours after permanent middle cerebral artery occlusion (pMCAO) in rats; also exhibits neuroprotective effects in mouse models of Parkinson's disease and Alzheimer's disease.
Technical Data for ONO 2506
| M. Wt | 186.29 |
| Formula | C11H22O2 |
| Storage | Store at +4°C |
| CAS Number | 185517-21-9 |
| PubChem ID | 208925 |
| InChI Key | YCYMCMYLORLIJX-SNVBAGLBSA-N |
| Smiles | CCC[C@H](CCCCCC)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ONO 2506
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.63 | 100 | |
| ethanol | 18.63 | 100 |
Preparing Stock Solutions for ONO 2506
The following data is based on the product molecular weight 186.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.37 mL | 26.84 mL | 53.68 mL |
| 5 mM | 1.07 mL | 5.37 mL | 10.74 mL |
| 10 mM | 0.54 mL | 2.68 mL | 5.37 mL |
| 50 mM | 0.11 mL | 0.54 mL | 1.07 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for ONO 2506
References for ONO 2506
References are publications that support the biological activity of the product.
Kato et al (2004) Arundic acid, an astrocyte-modulating agent, protects DArgic neurons against MPTP neurotoxicity in mice. Brain Res. 1030 66 PMID: 15567338
Tateishi et al (2002) Astrocytic activation and delayed infarct expansion after permanent focal ischemia in rats. Part II: suppression of astrocytic activation by a novel agent (R)-(-)-2-propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early J.Cereb.Blood Flow Metab. 22 723 PMID: 12045671
Mori et al (2006) Arundic acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice. J.Pharmacol.Exp.Ther. 318 571 PMID: 16709678
If you know of a relevant reference for ONO 2506, please let us know.
View Related Products by Target
Keywords: ONO 2506, ONO 2506 supplier, ONO2506, S100B, bbb, blood, brain, barrier, stroke, neuroprotective, Alzheimer's, parkinson's, disease, astrocytes, astrocytic, arundic, acid, parkinsons, alzheimers, Arundic, Neuronal, Metabolism, 4530, Tocris Bioscience
1 Citation for ONO 2506
Citations are publications that use Tocris products. Selected citations for ONO 2506 include:
Hao et al (2017) Arundic Acid Prevents Developmental Upregulation of S100B Expression and Inhibits Enteric Glial Development. Front Cell Neurosci 11 42 PMID: 28280459
Do you know of a great paper that uses ONO 2506 from Tocris? Please let us know.
Reviews for ONO 2506
There are currently no reviews for this product. Be the first to review ONO 2506 and earn rewards!
Have you used ONO 2506?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image