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Submit ReviewPCNA I1
Description: PCNA inhibitor
Chemical Name: N-(3-Methylthiophene-2-carboxylic acid)-N'-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide
Purity: ≥98% (HPLC)
Biological Activity for PCNA I1
PCNA I1 is a proliferating cell nuclear antigen (PCNA) inhibitor. Directly binds PCNA trimers (Kd = 0.41 μM), reduces chromatin-associated PCNA in cells, inhibits cell growth through induction of S and G2M arrest, and attenuates DNA replication in cells. Inhibits growth of a range of tumor cell lines in vitro with IC50 values in the nanomolar to low micromolar range. Inhibits growth of prostate tumor xenografts in mice.
Technical Data for PCNA I1
| M. Wt | 310.37 |
| Formula | C17H14N2O2S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 444930-42-1 |
| PubChem ID | 5410824 |
| InChI Key | WNYIQPCMVYAJLQ-JLHYYAGUSA-N |
| Smiles | O=C(C1=C(C)C=CS1)N/N=C/C2=C(O)C3=CC=CC=C3C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PCNA I1
References for PCNA I1
References are publications that support the biological activity of the product.
Tan et al (2012) Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth. Mol.Pharmacol. 81 811 PMID: 22399488
Dillehay et al (2014) Antitumor effects of a novel small molecule targeting PCNA chromatin association in prostate cancer. Mol.Cancer Ther. 13 2817 PMID: 25253786
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Keywords: PCNA I1, PCNA I1 supplier, PCNA11, Proliferating, cell, nuclear, antigen, PCNA, inhibits, inhibitors, anticancer, cycle, arrest, DNA,, RNA, and, Protein, Synthesis, 5419, Tocris Bioscience
Citations for PCNA I1
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Currently there are no citations for PCNA I1.
Reviews for PCNA I1
Average Rating: 5 (Based on 1 Review.)
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PCNAI1 quickly kills melanoma cells in vitro.
By
Anonymous on 02/14/2019
Assay Type: In Vitro
Species: Human
PCNA I1 was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.
Literature in this Area
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