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Submit ReviewPF 3084014 hydrobromide
Description: Potent γ-secretase inhibitor
Chemical Name: (2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]pentanamide dihydrobromide
Purity: ≥98% (HPLC)
Biological Activity for PF 3084014 hydrobromide
PF 3084014 hydrobromide is a potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for PF 3084014 hydrobromide
| M. Wt | 651.47 |
| Formula | C27H41F2N5O.HBr |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1962925-29-6 |
| PubChem ID | 121513889 |
| InChI Key | LXEYYZYDWLAIPW-KBVFCZPLSA-N |
| Smiles | O=C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)[C@H](CCC)N[C@H]2CCC1=CC(F)=CC(F)=C1C2.Br.Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PF 3084014 hydrobromide
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 6.51 | 10 with gentle warming | |
| DMSO | 65.15 | 100 |
Preparing Stock Solutions for PF 3084014 hydrobromide
The following data is based on the product molecular weight 651.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.53 mL | 7.67 mL | 15.35 mL |
| 5 mM | 0.31 mL | 1.53 mL | 3.07 mL |
| 10 mM | 0.15 mL | 0.77 mL | 1.53 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.31 mL |
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Product Datasheets for PF 3084014 hydrobromide
References for PF 3084014 hydrobromide
References are publications that support the biological activity of the product.
Lanz et al (2010) Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014. J.Pharmacol.Exp.Ther. 334 269 PMID: 20363853
If you know of a relevant reference for PF 3084014 hydrobromide, please let us know.
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Citations for PF 3084014 hydrobromide
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