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Phosphoramidon disodium salt

Cat. No. 6333 1 Citation Submit a Review Datasheet / COA / SDS
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Description: Neutral endopeptidase and endothelin converting enzyme inhibitor
Chemical Name: N-[N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt
Purity: ≥95% (HPLC)
Datasheet
Citations (1)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Phosphoramidon disodium salt

Phosphoramidon disodium salt is a neutral endopeptidase (neprilysin) inhibitor. Blocks degradation of amyloid β peptides and increases Aβ levels in rodents. Also blocks endothelin converting enzyme (ECE).

Technical Data for Phosphoramidon disodium salt

M. Wt 587.47
Formula C23H32N3Na2O10P
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 164204-38-0
PubChem ID 16219931
InChI Key OQKHVXFOYFBMDJ-ODIUWQMJSA-L
Smiles CC(C[C@@H](C(N[C@H](C(O[Na])=O)CC1=CNC2=CC=CC=C12)=O)NP(O[C@@H]3O[C@H]([C@@H]([C@H]([C@H]3O)O)O)C)(O[Na])=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Phosphoramidon disodium salt

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 58.75 100

Preparing Stock Solutions for Phosphoramidon disodium salt

The following data is based on the product molecular weight 587.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.7 mL 8.51 mL 17.02 mL
5 mM 0.34 mL 1.7 mL 3.4 mL
10 mM 0.17 mL 0.85 mL 1.7 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets for Phosphoramidon disodium salt

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Phosphoramidon disodium salt

References are publications that support the biological activity of the product.

Marr and Hafez (2014) Amyloid-beta and Alzheimer's disease: the role of neprilysin-2 in amyloid-beta clearance. Front.Aging Neurosci. 6 187 PMID: 25165447

Shirotani et al (2001) Neprilysin degrades both amyloid β peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases. J.Biol.Chem. 276 21895 PMID: 11278416

Warner et al (1992) Regional differences in endothelin converting enzyme activity in rat brain: inhibition by phosphoramidon and EDTA. Br.J.Pharmacol. 106 948 PMID: 1393292

If you know of a relevant reference for Phosphoramidon disodium salt, please let us know.

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Keywords: Phosphoramidon disodium salt, Phosphoramidon disodium salt supplier, neprilysin, neutral, metallo, endopeptidase, endothelin, converting, enzyme, ECE, inhibitors, inhibits, 119942-99-3, NEP, CD10, MME, Other, Proteases, 6333, Tocris Bioscience

1 Citation for Phosphoramidon disodium salt

Citations are publications that use Tocris products. Selected citations for Phosphoramidon disodium salt include:

Bruce L et al (2021) Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration. Mol Neurodegener 16 51 PMID: 34344440

Do you know of a great paper that uses Phosphoramidon disodium salt from Tocris? Please let us know.

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