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Submit ReviewPLP (139-151)
Description: Encephalitogenic myelin proteolipid fragment
Alternative Names: Proteolipid protein (139-151)
Purity: ≥95% (HPLC)
Biological Activity for PLP (139-151)
PLP (139-151) is a synthetic myelin proteolipid protein (PLP) fragment. Immunization with this peptide induces severe clinical and histological experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis.
Technical Data for PLP (139-151)
| M. Wt | 1521.74 |
| Formula | C72H104N20O17 |
| Sequence | HSLGKWLGHPDKF |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 122018-58-0 |
| PubChem ID | 16199055 |
| InChI Key | UQIBUOXNUPHALR-UVIWMAFZSA-N |
| Smiles | [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PLP (139-151)
| Solubility | Soluble to 2 mg/ml in water |
Product Datasheets for PLP (139-151)
References for PLP (139-151)
References are publications that support the biological activity of the product.
Tuohy et al (1989) Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J.Immunol. 142 1523 PMID: 2465343
Sobel et al (1990) Acute experimental allergic encephalomyelitis in SJL/J mice induced by a synthetic peptide of myelin proteolipid protein. J.Neuropathol.Exp.Neurol. 49 468 PMID: 2273404
Kuchroo et al (1991) Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. Pathobiology. 59 305 PMID: 1716908
If you know of a relevant reference for PLP (139-151), please let us know.
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Keywords: PLP (139-151), PLP (139-151) supplier, Encephalitogenic, myelin, proteolipid, fragment, Neuronal, Metabolism, multiple, sclerosis, encephalomyelitis, EAE, Proteolipid, protein, (139-151), 2567, Tocris Bioscience
3 Citations for PLP (139-151)
Citations are publications that use Tocris products. Selected citations for PLP (139-151) include:
Jana et al (2012) Gemfibrozil, a lipid-lowering drug, increases myelin genes in human oligodendrocytes via peroxisome proliferator-activated receptor-β. J Biol Chem 287 34134 PMID: 22879602
Mondal et al (2012) Regulation of encephalitogenicity of neuroantigen-primed T cells by nitric oxide: Implications for multiple sclerosis. J Clin Cell Immunol 3 124 PMID: 23275862
Arima et al (2015) A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model. Elife 4 PMID: 26193120
Do you know of a great paper that uses PLP (139-151) from Tocris? Please let us know.
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