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Submit ReviewPrion Protein 106-126 (human)
Description: Prion protein fragment
Biological Activity for Prion Protein 106-126 (human)
Prion Protein 106-126 (human) is a prion peptide fragment that shares many physiochemical features with PrPSc. Exhibits neurotoxicity caused by amplification of PrPC-associated signaling responses and induces NF-κB-mediated apoptosis in the mouse neuroblastoma cell line N2a. Forms β-sheet-rich, insoluble, protease-resistant fibrils and is used as a model to study prion diseases in vitro.
Technical Data for Prion Protein 106-126 (human)
| M. Wt | 1912.26 |
| Formula | C80H138N26O24S2 |
| Sequence | KTNMKHMAGAAAAGAVVGGLG |
| Storage | Desiccate at -20°C |
| CAS Number | 148439-49-0 |
| PubChem ID | 16135249 |
| InChI Key | XPZWWTIIKSODDO-MBNDGZRNSA-N |
| Smiles | [H]N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Prion Protein 106-126 (human)
References for Prion Protein 106-126 (human)
References are publications that support the biological activity of the product.
Forloni et al (1993) Neurotoxicity of a prion protein fragment. Nature 362 543 PMID: 8464494
Pietri et al (2006) Overstimulation of PrPC signaling pathways by prion peptide 106-126 causes oxidative injury of bioaminergic neuronal cells. J.Biol.Chem. 281 28470 PMID: 16864581
Bai et al (2008) p75NTR activation of NF-κB is involved in PrP106-126-induced apoptosis in mouse neuroblastoma cells. Neurosci.Res. 62 9 PMID: 18602709
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Keywords: Prion Protein 106-126 (human), Prion Protein 106-126 (human) supplier, Prion, protein, fragment, PrPSc, Antiprion, Neuronal, Metabolism, Protein, 3491, Tocris Bioscience
1 Citation for Prion Protein 106-126 (human)
Citations are publications that use Tocris products. Selected citations for Prion Protein 106-126 (human) include:
Domizio et al (2012) Binding with nucleic acids or glycosaminoglycans converts soluble protein oligomers to amyloid. J Biol Chem 287 736 PMID: 22102410
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Pathways for Prion Protein 106-126 (human)
