Home / Pharmacology / Enzymes / Proteases / Proteasome / Proteasome Inhibitors / (R)-MG 132

(R)-MG 132

Cat. No. 6033 3 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent 20S proteasome inhibitor
Chemical Name: N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-D-leucinamide
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for (R)-MG 132

(R)-MG 132 is a potent 20S proteasome inhibitor (IC50 = 0.22 nM). Exhibits cytostatic and cytotoxic effects in tumor cells in vitro.

Technical Data for (R)-MG 132

M. Wt 475.63
Formula C26H41N3O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1211877-36-9
PubChem ID 45103781
InChI Key TZYWCYJVHRLUCT-ZRBLBEILSA-N
Smiles CC(C[C@@H](C=O)NC([C@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)CC(C)C)=O)CC(C)C)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (R)-MG 132

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 47.56 100
ethanol 9.51 20

Preparing Stock Solutions for (R)-MG 132

The following data is based on the product molecular weight 475.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.1 mL 10.51 mL 21.02 mL
5 mM 0.42 mL 2.1 mL 4.2 mL
10 mM 0.21 mL 1.05 mL 2.1 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for (R)-MG 132

References are publications that support the biological activity of the product.

Mroczkiewicz et al (2010) Studies of the synthesis of all stereoisomers of MG-132 proteasome inhibitors in the tumor targeting approach. J.Med.Chem. 53 1509 PMID: 20112914

If you know of a relevant reference for (R)-MG 132, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Proteasome Inhibitors

Keywords: (R)-MG 132, (R)-MG 132 supplier, (R)-MG132, 20S, proteasome, inhibitors, inhibits, potent, Proteasome, 6033, Tocris Bioscience

3 Citations for (R)-MG 132

Citations are publications that use Tocris products. Selected citations for (R)-MG 132 include:

Armando A et al (2022) Calcineurin Controls Cellular Prion Protein Expression in Mouse Astrocytes. Cells 11 PMID: 35203261

Eleonora et al (2020) Calcineurin Controls Expression of EAAT1/GLAST in Mouse and Human Cultured Astrocytes through Dynamic Regulation of Protein Synthesis and Degradation. Int J Mol Sci 21 PMID: 32210081

C David et al (2019) Identification of Novel RAS Signaling Therapeutic Vulnerabilities in Diffuse Intrinsic Pontine Gliomas. Cancer Res 79 4026-4041 PMID: 31201162

Do you know of a great paper that uses (R)-MG 132 from Tocris? Please let us know.

Reviews for (R)-MG 132

There are currently no reviews for this product. Be the first to review (R)-MG 132 and earn rewards!

Have you used (R)-MG 132?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia