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Submit ReviewS3QEL 2
Discontinued Product
5735 has been discontinued.
Description: Suppressor of complex III superoxide production
Chemical Name: 1-(3,4-Dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥98% (HPLC)
Biological Activity for S3QEL 2
Suppresses superoxide production by complex III in the mitochondria without affecting normal electron flux or cellular oxidative phosphorylation (IC50 = 1.7 μM). Suppresses HIF-1α accumulation and enhances survival and function of primary pancreatic islets in vitro. Cell permeable.
Technical Data for S3QEL 2
| M. Wt | 323.44 |
| Formula | C19H25N5 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 890888-12-7 |
| PubChem ID | 17017624 |
| InChI Key | MGIAJZSCNPODRR-UHFFFAOYSA-N |
| Smiles | CC(C(C)=C1)=CC=C1N2C3=NC=NC(N(CCC)CCC)=C3C=N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for S3QEL 2
References for S3QEL 2
References are publications that support the biological activity of the product.
Orr et al (2015) Suppressors of superoxide production from mitochondrial complex III. Nat.Chem.Biol. 11 834 PMID: 26368590
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Keywords: S3QEL 2, S3QEL 2 supplier, S3QEL2, Suppresses, superoxide, production, complex, III, mitochondria, oxidative, phosphorylation, ROS, reactive, oxygen, species, inhibitors, inhibits, Donors, Oxidative, Phosphorylation, 5735, Tocris Bioscience
Citations for S3QEL 2
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