Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewSacubitril calcium
Description: Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug; orally bioavailable
Alternative Names: AHU 377
Chemical Name: Ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoate hemicalcium salt
Purity: ≥98% (HPLC)
Biological Activity for Sacubitril calcium
Sacubitril calcium is a membrane metallo-endopeptidase (neprilysin) inhibitor prodrug. Increases ANF-induced natriuresis without affecting diuresis in rats. Orally bioavailable.
Compound Libraries for Sacubitril calcium
Sacubitril calcium is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Sacubitril calcium
| M. Wt | 430.52 |
| Formula | C24H28NO5.½Ca |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1369773-39-6 |
| PubChem ID | 91827885 |
| InChI Key | DDLCKLBRBPYKQS-OXXXZDCLSA-L |
| Smiles | [Ca++].C[C@@H](C(OCC)=O)C[C@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1.C[C@@H](C(OCC)=O)C[C@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Sacubitril calcium
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.05 | 100 | |
| ethanol | 8.61 | 20 |
Preparing Stock Solutions for Sacubitril calcium
The following data is based on the product molecular weight 430.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.32 mL | 11.61 mL | 23.23 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.65 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Sacubitril calcium
References for Sacubitril calcium
References are publications that support the biological activity of the product.
Ksander et al (1995) Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J.Med.Chem. 38 1689 PMID: 7752193
If you know of a relevant reference for Sacubitril calcium, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Sacubitril calcium, Sacubitril calcium supplier, AHU377, NEP, neprilysin, neutral, MME, membrane, metallo-endopeptidase, inhibitors, inhibits, prodrug, orally, bioavailable, natriuretic, natriuresis, ANF, CD10, AHU, 377, Other, Proteases, 5772, Tocris Bioscience
Citations for Sacubitril calcium
Citations are publications that use Tocris products.
Currently there are no citations for Sacubitril calcium. Do you know of a great paper that uses Sacubitril calcium from Tocris? Please let us know.
Reviews for Sacubitril calcium
There are currently no reviews for this product. Be the first to review Sacubitril calcium and earn rewards!
Have you used Sacubitril calcium?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image