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SBP1-FITC

Cat. No. 7232 Submit a Review Datasheet / COA / SDS

Discontinued Product

7232 has been discontinued.

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Description: Fluorescent ACE2-derived peptide; binds receptor binding domain of SARS-CoV-2 spike protein
Purity: ≥95% (HPLC)
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Biological Activity Technical Data Datasheets References

Biological Activity for SBP1-FITC

SBP1-FITC is a fluorescently labelled peptide derived from human ACE2 (SBP1, Cat. No. 7233). Composed of SBP1 conjugated to FITC (Fluorescein-5-isothiocyanate; Cat. No. 5440). SBP1 binds receptor binding domain (RBD) of insect-derived SARS-CoV-2 spike protein (KD = 1.3 μM for N-terminal biotinylated, insect-derived spike protein RBD; see Zhang et al preprint publication).

Please note - unpublished, in-house data suggests SBP1 has approximately 75-fold lower affinity for insect-derived SARS-CoV-2 RBD than reported by Zhang et al.

Technical Data for SBP1-FITC

M. Wt 3438.68
Formula C159H217N33O51S
Sequence IEEQAKTFLDKFNHEAEDLFYQS

(Modifications: Ile-1 = FITC-PEG4-Ile, Ser-23 = C-terminal amide)
Storage Store at -20°C
Purity ≥95% (HPLC)
InChI Key XEJQYVVTMPCYCP-TVTAXLCZSA-N
Smiles O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(N)=O)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CO)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@@H](C)CC)NC(CCOCCOCCOCCOCCNC(NC(C=C6C(O)=O)=CC=C6C(C7=CC=C(O)C=C7O8)=C(C=C9)C8=CC9=O)=S)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for SBP1-FITC

References are publications that support the biological activity of the product.

Zhang et al (2020) The first-in-class peptide binder to the SARS-CoV-2 spike protein. BioRxiv - Paper not yet peer reviewed.

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Keywords: SBP1-FITC SBP1-FITC, SBP1-FITC SBP1-FITC supplier, spike, binding, protein, SARS-CoV-2, receptor, domain, RBD, COVID-19, severe, acute, respiratory, syndrome, ACE2, peptide, fluorescently-labeled, flluorescence, Enzyme, Probes, and, Substrates, 7232, Tocris Bioscience

Citations for SBP1-FITC

Citations are publications that use Tocris products.

Currently there are no citations for SBP1-FITC.

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