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Selinexor

Cat. No. 7760 Submit a Review Datasheet / COA / SDS
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Description: Selective exportin 1 (XPO1/CRM1) inhibitor
Chemical Name: (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Selinexor

Selinexor is an inhibitor of the exportin 1 (XPO1/CRM1) nuclear exporter. Shows selectivity for TNBC over ER-positive breast cancer cell lines (IC50 values are 11-550 nM and >1000 nM, respectively), and reduces growth of xenografts. Inhibits growth of thyroid cancer cell lines (IC50 = 150-500 nM), potentiates the anti-tumor effects of Olaparib (Cat. No. 7579) in ovarian cancer and breast cancer. Also a potent inhibitor of SARS-CoV-2 replication in vitro (EC50 = 10 nM) and downregulates the production of pro-inflammatory cytokines including TNF-α and IL-6.

Technical Data for Selinexor

M. Wt 443.31
Formula C17H11F6N7O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1393477-72-9
PubChem ID 71481097
InChI Key DEVSOMFAQLZNKR-RJRFIUFISA-N
Smiles O=C(NNC1=NC=CN=C1)/C=C\N(C=N2)N=C2C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Selinexor

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.33 100
ethanol 22.17 50

Preparing Stock Solutions for Selinexor

The following data is based on the product molecular weight 443.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.28 mL 22.56 mL
5 mM 0.45 mL 2.26 mL 4.51 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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References for Selinexor

References are publications that support the biological activity of the product.

Arango et al (2017) Selinexor (KPT-330) demonstrates anti-tumor efficacy in preclinical models of triple-negative breast cancer. Breast Cancer Res. 19 93 PMID: 28810913

Marijon et al (2021) Selinexor, a selective inhibitor of nuclear export, enhances the anti-tumor activity of olaparib in triple negative breast cancer regardless of BRCA1 mutation status. Oncotarget. 12 1749 PMID: 34504648

Kashyap et al (2021) Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo. Antiviral Res. 192 105115 PMID: 34157321

If you know of a relevant reference for Selinexor, please let us know.

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Keywords: Selinexor, Selinexor supplier, selective, inhibitors, exportin, nuclear, exporter, XPO1, CRM1, triple, negative, breast, cancer, thyroid, SARS-CoV-2, cytokines, DNA,, RNA, and, Protein, Synthesis, Coronavirus, 7760, Tocris Bioscience

Citations for Selinexor

Citations are publications that use Tocris products.

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Literature in this Area

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