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SJ 6986

Cat. No. 7720 Submit a Review Datasheet / COA / SDS
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Description: Molecular glue; induces degradation of GSPT1/2
Chemical Name: N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SJ 6986

SJ 6986 is a potent and selective GSPT1/2 molecular glue Degrader (DC50 = 2.1 nM). The Degrader exhibits antiproliferative effects in human medulloblastoma and leukemia cell lines. (EC50 values are 0.4 nM, 1.5 nM, 336 nM, 726 nM and 3583 nM in MHH-CALL-4, MV4-11, MB004, MB002 and HD-MB03 cell lines, respectively). In vivo, SJ 6986 is stable in mouse (t1/2 = 4.7 h). This product is orally bioavailable.

Licensing Information

Sold under license from St. Jude Children's Research Hospital.

Technical Data for SJ 6986

M. Wt 497.4
Formula C20H14F3N3O7S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2765625-93-0
PubChem ID 155925914
InChI Key RKAFYSIKAVFVPS-UHFFFAOYSA-N
Smiles O=S(C1=CC=CC=C1OC(F)(F)F)(NC2=CC(C(N3C4C(NC(CC4)=O)=O)=O)=C(C=C2)C3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SJ 6986

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.74 100

Preparing Stock Solutions for SJ 6986

The following data is based on the product molecular weight 497.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.01 mL 10.05 mL 20.1 mL
5 mM 0.4 mL 2.01 mL 4.02 mL
10 mM 0.2 mL 1.01 mL 2.01 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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References for SJ 6986

References are publications that support the biological activity of the product.

Nishiguchi et al (2021) Identification of potent, selective, and orally bioavailable small- molecule GSPT1/2 degraders from a focused library of cereblon modulators. J.Med.Chem. 64 7296 PMID: 34042448

If you know of a relevant reference for SJ 6986, please let us know.

View Related Products by Target

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Citations for SJ 6986

Citations are publications that use Tocris products.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

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