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Stattic

Cat. No. 2798 18 Citations 2 Reviews Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective STAT3 inhibitor
Chemical Name: 6-Nitrobenzo[b]thiophene 1,1-dioxide
Purity: ≥98% (HPLC)
Datasheet
Citations (18)
Reviews (2)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Stattic

Stattic is a small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.

Technical Data for Stattic

M. Wt 211.19
Formula C8H5NO4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 19983-44-9
PubChem ID 2779853
InChI Key ZRRGOUHITGRLBA-UHFFFAOYSA-N
Smiles O=S2(C1=CC([N+]([O-])=O)=CC=C1C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Stattic

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.56 50

Preparing Stock Solutions for Stattic

The following data is based on the product molecular weight 211.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 9.47 mL 47.35 mL 94.7 mL
2.5 mM 1.89 mL 9.47 mL 18.94 mL
5 mM 0.95 mL 4.74 mL 9.47 mL
25 mM 0.19 mL 0.95 mL 1.89 mL

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Product Datasheets for Stattic

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Stattic

References are publications that support the biological activity of the product.

Schust et al (2006) Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem.Biol. 13 1235 PMID: 17114005

If you know of a relevant reference for Stattic, please let us know.

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Keywords: Stattic, Stattic supplier, Selective, STAT3, inhibitors, inhibits, STAT, Transcription, Factors, Signal, Transducers, activators, Cytokine, NF-κB, NF-kappaB, Signaling, Signalling, 2798, Tocris Bioscience

18 Citations for Stattic

Citations are publications that use Tocris products. Selected citations for Stattic include:

Fan et al (2018) Modulation of nuclear factor-kappa B activation by the endoplasmic reticulum stress sensor PERK to mediate estrogen-induced apoptosis in breast cancer cells. Cell Death Discov 4 15 PMID: 29531812

Banerjee et al (2017) Reduced FAK-STAT3 signaling contributes to ER stress-induced mitochondrial dysfunction and death in endothelial cells. Cell Signal 36 154 PMID: 28495589

Natarajan et al (2014) STAT3 modulation to enhance motor neuron differentiation in human neural stem cells. Cancer Res 9 e100405 PMID: 24945434

Shravah et al (2014) PropF. mediates signal transducer and activator of transcription 3 activation and crosstalk with phosphoinositide 3-kinase/AKT. Nat Commun 3 e29554 PMID: 25105067

Price et al (2013) Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations. JAKSTAT 73 3441 PMID: 23729642

Dong et al (2017) Interleukin-22 participates in the inflammatory process of vitiligo. Oncotarget 8 109161 PMID: 29312598

Keasey et al (2013) Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression. Cell Commun Signal 11 35 PMID: 23693126

Haynes et al (2013) Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration. Nat Commun 4 2312 PMID: 23942241

Beales and Ogunwobi (2009) Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation. J Mol Endocrinol 42 305 PMID: 19153190

Ko et al (2016) STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin M through Induction of Matrix Metalloproteinases 2 and 9. Yonsei Med J 57 761 PMID: 26996579

Peda et al (2016) Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease. Dis Model Mech 9 1051 PMID: 27491076

Liu et al (2013) Stat3 inhibition attenuates mechanical allodynia through transcriptional regulation of chemokine expression in spinal astrocytes. PLoS One 8 e75804 PMID: 24098399

Katz et al (2012) Targeting of Rac GTPases blocks the spread of intact human breast cancer. Oncotarget 3 608 PMID: 22689141

Hodge et al (2012) IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia. Blood 120 3774 PMID: 22976953

Petes et al (2018) Interleukin (IL)-6 Inhibits IL-27- and IL-30-Mediated Inflammatory Responses in Human Monocytes. Front Immunol 9 256 PMID: 29497424

Visavadiya (2016) Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Communication and Signaling 14 32 PMID: 27978828

Conner et al (2014) Repressing notch signaling and expressing TNFα are sufficient to mimic retinal regeneration by inducing Müller glial proliferation to generate committed progenitor cells. J Neurosci 34 14403 PMID: 25339752

Okada et al (2015) STAT3 signaling contributes to the high effector activities of interleukin-15-derived dendritic cells. PLoS One 93 461 PMID: 25582338

Do you know of a great paper that uses Stattic from Tocris? Please let us know.

Reviews for Stattic

Average Rating: 4 (Based on 2 Reviews.)

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Mitochondrial bioenergetics measurements by reagent screen.
By Anonymous on 03/15/2020
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: mouse brain endothelioma cell line

10 μM

PMID: 27978828
review image
Static inhibition of STAT3 pathway.
By Mark Stauffer on 01/04/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: U87

Used to potentially inhibit signal transduction of the stat3 pathway in U87 cells, and was compared with other potential inhibitors in their effectivness of signal transduction when treating cells with pathway activators. It was assessed using RT-PCR for markers of pathway activation to see what inhibitor was most effective.

Pathways for Stattic

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.