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Description: PCNA inhibitor
Chemical Name: (βS)-β-Amino-4-(4-hydroxyphenoxy)-3,5-diiodobenzenpropanol
Purity: ≥98% (HPLC)
Biological Activity for T2AA
T2AA is a proliferating cell nuclear antigen (PCNA) inhibitor; inhibits PCNA/PIP-box peptide interaction (IC50 ~1 μM). Causes DNA replication stress by stalling DNA replication forks. Inhibits PCNA interaction with DNA polymerase δ and arrests cell growth in S-phase. Suppresses cancer cell growth.
Licensing Information
Sold under license from St. Jude Childrens Research Hospital
Technical Data for T2AA
| M. Wt | 511.09 |
| Formula | C15H15I2NO3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1380782-27-3 |
| PubChem ID | 71185540 |
| InChI Key | NKOSKXJRVWVXRI-JTQLQIEISA-N |
| Smiles | IC1=C(OC2=CC=C(O)C=C2)C(I)=CC(C[C@H](N)CO)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for T2AA
References for T2AA
References are publications that support the biological activity of the product.
Punchihewa et al (2012) Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J.Biol.Chem. 287 14289 PMID: 22383522
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Keywords: T2AA, T2AA supplier, Proliferating, cell, nuclear, antigen, PCNA, inhibitors, inhibits, DNA, replication, forks, DNA,, RNA, and, Protein, Synthesis, Polymerase, 4723, Tocris Bioscience
1 Citation for T2AA
Citations are publications that use Tocris products. Selected citations for T2AA include:
Carl L et al (2020) Dynamic Assembly and Disassembly of the Human DNA Polymerase δ Holoenzyme on the Genome In Vivo. Cell Rep 30 1329-1341.e5 PMID: 32023453
Reviews for T2AA
Average Rating: 5 (Based on 1 Review.)
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T2AA completely kills melanoma cell line at micromolar concentrations.
By
Anonymous on 02/07/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: SK-MEL-28
Used for killing assay for in vitro cell culture. Cells were cultured for 24 hours before the addition of the compound into the media at low micromolar concentrations (indicated by the arrow).
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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