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Targapremir 210

Cat. No. 6586 Submit a Review Datasheet / COA / SDS
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Description: Inhibits formation of miR-210
Chemical Name: N-(3-Azidopropyl)-4-[3-[6-(4-methyl-1-piperazinyl)[2,6'-bi-1H-benzimidazol]-2'-yl]phenoxy]butanamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Targapremir 210

Targapremir 210 inhibits formation of mature miR-210 (IC50 = 200 nM) by binding to Dicer binding site of the miR-210 hairpin precursor (Kd = 200 nM) and inhibits Dicer processing of the miRNA. Decreases levels of miR-210 and HIF-1α mRNA, and induces apoptosis in MDA-MB-231 cells cultured under hypoxic conditions. Reduces tumor expression of HIF-1α mRNA and miR-210, and tumor growth in a triple negative breast cancer mouse model.

Technical Data for Targapremir 210

M. Wt 592.71
Formula C32H36N10O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1049722-30-6
PubChem ID 44221088
InChI Key PAYVJEWMAWLKAP-UHFFFAOYSA-N
Smiles CN1CCN(C2=CC=C3N=C(C4=CC=C5N=C(C6=CC(OCCCC(NCCCN=[N+]=[N-])=O)=CC=C6)NC5=C4)NC3=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Targapremir 210

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 59.27 100
ethanol 59.27 100

Preparing Stock Solutions for Targapremir 210

The following data is based on the product molecular weight 592.71. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.69 mL 8.44 mL 16.87 mL
5 mM 0.34 mL 1.69 mL 3.37 mL
10 mM 0.17 mL 0.84 mL 1.69 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets for Targapremir 210

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Targapremir 210

References are publications that support the biological activity of the product.

Costales et al (2017) Small molecule inhibition of microRNA-210 reprograms an oncogenic hypoxic circuit. J.Am.Chem.Soc. 139 3446 PMID: 28240549

Childs-Disney et al (2012) Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive. ACS.Chem.Biol 7 856 PMID: 22332923

If you know of a relevant reference for Targapremir 210, please let us know.

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Keywords: Targapremir 210, Targapremir 210 supplier, micro, RNA, miRNA, inhibitors, inhibits, miR-210, triple, negative, breast, cancer, hypoxia, HIF1a, alpha, alfa, α, DNA,, and, Protein, Synthesis, 6586, Tocris Bioscience

Citations for Targapremir 210

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Literature in this Area

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