Home / Cell Biology / Cell Metabolism / DNA, RNA and Protein Synthesis / DNA, RNA and Protein Synthesis Inhibitors / TC SL C5

TC SL C5

Cat. No. 6884 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor
Alternative Names: SM5,MALAT1-IN-1
Chemical Name: 5-(4-Methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-1-methyl-1H-Imidazol-2-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TC SL C5

TC SL C5 is a metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor (KD = 2.9 μM). Binds Malat1 3' terminal stability element for nuclear expression (ENE) triplex. Reduces Malat1 RNA levels by 54% and branching morphogenesis by 38% in mammary tumor organoids. Modulates Malat1 downstream genes without affecting Neat1.

Compound Libraries for TC SL C5

TC SL C5 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TC SL C5

M. Wt 323.4
Formula C19H21N3O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 827327-28-6
PubChem ID 1096509
InChI Key LCVOJBGSGIOMKF-UHFFFAOYSA-N
Smiles COC1=CC=C(C=C1)C1=CN=C(NCC2=CC(OC)=CC=C2)N1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC SL C5

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.34 100
ethanol 32.34 100

Preparing Stock Solutions for TC SL C5

The following data is based on the product molecular weight 323.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.09 mL 15.46 mL 30.92 mL
5 mM 0.62 mL 3.09 mL 6.18 mL
10 mM 0.31 mL 1.55 mL 3.09 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for TC SL C5

References are publications that support the biological activity of the product.

Abulwerdi et al (2019) Selective small-molecule targeting of a triple helix encoded by the long noncoding RNA, MALAT1. ACS Chem.Biol. 14 223 PMID: 30620551

If you know of a relevant reference for TC SL C5, please let us know.

View Related Products by Target

View Related Products by Product Action

View all DNA, RNA and Protein Synthesis Inhibitors

Keywords: TC SL C5, TC SL C5 supplier, TCSLC5, MALAT1, Metastasis-associated, lung, adenocarcinoma, transcript, 1, RNA, inhibitors, inhibits, breast, cancer, element, for, nuclear, expression, ENE, triplex, SM5, MALAT1IN1, MALAT1-IN-1, DNA,, and, Protein, Synthesis, 6884, Tocris Bioscience

Citations for TC SL C5

Citations are publications that use Tocris products.

Currently there are no citations for TC SL C5. Do you know of a great paper that uses TC SL C5 from Tocris? Please let us know.

Reviews for TC SL C5

There are currently no reviews for this product. Be the first to review TC SL C5 and earn rewards!

Have you used TC SL C5?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Huntington's Disease Research Product Guide

Huntington's Disease Research Product Guide

This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:

  • Somatic Instability
  • Proteolysis and Inclusion Bodies
  • Transcriptional Dysregulation
  • Mitochondrial Dysfunction
  • Nuclear-Cytoplasmic Transport Interference
  • Excitotoxicity
  • Stem Cells