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Description: NIR-emission luciferin analog; ideal for deep tissue applications; orally bioavailable and brain penetrant
Alternative Names: AkaLumine HCl
Chemical Name: (4S)-2-[(1E,3E)-4-[4-(Dimethylamino)phenyl]-1,3-butadien-1-yl]-4,5-dihydro-4-thiazolecarboxylic acid hydrochloride
Purity: ≥90% (HPLC)
Biological Activity for TokeOni
TokeOni is a near-infrared red (NIR)-emission luciferin analog. Peak luminescence at 677 nM. ~40-fold brighter than the luciferin-luciferase system in vitro, and 100-1000 times brighter in vivo. Allows non-invasive visualization of single cells deep inside freely moving animals. Ideal for deep tissue applications. Water soluble (<40 mM), orally bioavailable and brain penetrant.
This product is supplied as a hydrochloride salt, the stoichiometry of which is batch dependant. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.
Optical Data for TokeOni
| Emission Color | Near-IR |
|---|---|
| λem | 677 nm |
| Application | BLI, BTI, Deep Tissue Applications |
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Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
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Technical Data for TokeOni
| M. Wt | 302.39 (Free Base) |
| Formula | C16H18N2O2S.xHCl |
| Storage | Store at -20°C |
| Purity | ≥90% (HPLC) |
| PubChem ID | 124203055 |
| InChI Key | PZCNKVAGZCXXHX-SSRSOBHISA-N |
| Smiles | CN(C1=CC=C(C=C1)/C=C/C=C/C2=N[C@@H](C(O)=O)CS2)C.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TokeOni
| Solubility | Soluble to 5 mg/ml in water with gentle warming and to 10 mg/ml in DMSO |
Product Datasheets for TokeOni
References for TokeOni
References are publications that support the biological activity of the product.
Kuchimaru et al (2016) A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging. Nat. Commun. 7 11856 PMID: 27297211
Nasu et al (2018) Unnaturally aglow with a bright inner light. Science 359 868 PMID: 29472468
Iwano et al (2018) Single-cell bioluminescence imaging of deep tissue in freely moving animals. Science 359 935 PMID: 29472486
If you know of a relevant reference for TokeOni, please let us know.
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Keywords: TokeOni, TokeOni supplier, AkaLumine, HCl, Aka, Lumine, Near, infrared, red, NIR, emission, luciferin, analogues, orally, bioavailable, brain, penetrant, BBB, blood, barrier, permeable, analogs, bioluminescence, BLI, BTI, Biochemicals, and, Molecular, Biology, Bioluminescent, Substrates, 6555, Tocris Bioscience
1 Citation for TokeOni
Citations are publications that use Tocris products. Selected citations for TokeOni include:
Vivien et al (2022) Firefly luciferase offers superior performance to AkaLuc for tracking the fate of administered cell therapies. Eur J Nucl Med Mol Imaging 49 796-808 PMID: 34313817
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Fluorescent Dyes and Probes Research Product Guide
This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:
- Fluorescent Dyes, including dyes for flow cytometry
- Fluorescent Probes and Stains, including our new MitoBrilliantTM mitochondria stains
- Tissue Clearing Kits and Reagents
- Aptamer-based RNA Imaging Reagents
- Fluorescent Probes for Imaging Bacteria
- TSA VividTM Fluorophore Kits
- TSA Reagents for Enhancing IHC, ICC & FISH Signals