Home / Product Type / Reagents / Protein Dimerizers / TRAM 1

TRAM 1

Cat. No. 8121 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Chemical inducer of proximity for dTAG protein FKBPF36V and ecDHFR tags
Chemical Name: (R)-1-(3-(2-((3-(4-((2,4-Diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)propyl)amino)-2-oxoethoxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TRAM 1

TRAM 1 is a targeted relocalization activating molecule (TRAM) and chemical inducer of proximity for the dTAG protein FKBP12F36V and ecDHFR tags. Can be used to shuttle and redistribute proteins in live cells.

Technical Data for TRAM 1

M. Wt 1009.17
Formula C54H68N6O13
Storage Store at -20°C
Purity ≥98% (HPLC)
InChI Key SGECTVFBOKCZAI-YZBUDRBASA-N
Smiles O=C(O[C@H](CCC1=CC(OC)=C(C=C1)OC)C2=CC(OCC(NCCCOC3=C(C=C(C=C3OC)CC4=CN=C(N=C4N)N)OC)=O)=CC=C2)[C@@H]5CCCCN5C([C@@H](CC)C6=CC(OC)=C(C(OC)=C6)OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TRAM 1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100.92 100

Preparing Stock Solutions for TRAM 1

The following data is based on the product molecular weight 1009.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.99 mL 4.95 mL 9.91 mL
5 mM 0.2 mL 0.99 mL 1.98 mL
10 mM 0.1 mL 0.5 mL 0.99 mL
50 mM 0.02 mL 0.1 mL 0.2 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for TRAM 1

References are publications that support the biological activity of the product.

Ng et al (2024) Targeted protein relocalization via protein transport coupling. Nature PMID: 39294374

If you know of a relevant reference for TRAM 1, please let us know.

View Related Products by Target

Keywords: TRAM 1, TRAM 1 supplier, TRAM1, targeted, relocalization, activation, molecules, dTAG, FKBP12, FKBP12F36V, cereblon, degrade, degrader, degradation, dhfr, tag, degron, chemical, inducer, of, proximity, Protein, Dimerizers, 8121, Tocris Bioscience

Citations for TRAM 1

Citations are publications that use Tocris products.

Currently there are no citations for TRAM 1. Do you know of a great paper that uses TRAM 1 from Tocris? Please let us know.

Reviews for TRAM 1

There are currently no reviews for this product. Be the first to review TRAM 1 and earn rewards!

Have you used TRAM 1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review