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Submit ReviewTramiprosate
Discontinued Product
3619 has been discontinued.
Description: Targets soluble Aβ to decrease amyloid plaque deposition. Also GABA analog
Alternative Names: Homotaurine
Chemical Name: 3-Amino-1-propanesulfonic acid
Biological Activity for Tramiprosate
Tramiprosate is a sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (Aβ) and maintains Aβ in a non-fibrillar form. Decreases Aβ42-induced neuronal death and inhibits amyloid deposition in vitro. Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo.
Technical Data for Tramiprosate
| M. Wt | 139.17 |
| Formula | C3H9NO3S |
| Storage | Store at +4°C |
| CAS Number | 3687-18-1 |
| PubChem ID | 1646 |
| InChI Key | SNKZJIOFVMKAOJ-UHFFFAOYSA-N |
| Smiles | NCCCS(=O)(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Tramiprosate
References for Tramiprosate
References are publications that support the biological activity of the product.
Fariello et al (1982) Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid. Neurology 32 241 PMID: 7199633
Gervais et al (2007) Targeting soluble Aβ peptide with tramiprosate for the treatment of brain amyloidosis. Neurobiol.Aging 28 537 PMID: 16675063
Santa-Maria et al (2007) Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau. Mol.Neurodegen. 2 17
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Keywords: Tramiprosate, Tramiprosate supplier, Sulfated, glycosaminoglycan, sGAG, Targets, soluble, Amyloid-beta, β-Amyloid, beta-Amyloid, b-amyloid, decrease, amyloid, plaque, deposition, Precursor, Protein, APP, Secretase, beta, Peptides, GABAA, GABAC, GABAB, Receptors, analogue, amyloidb, amyloidβ, Homotaurine, Amyloid, Beta, Miscellaneous, GABA, 3619, Tocris Bioscience
Citations for Tramiprosate
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Currently there are no citations for Tramiprosate.
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Literature in this Area
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Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.