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Submit ReviewVerubecestat
Description: BACE1 and BACE2 inhibitor
Chemical Name: N-[3-[(5R)-3-Amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide
Purity: ≥98% (HPLC)
Biological Activity for Verubecestat
Verubecestat is a high affinity and selective β-secretase 1 (BACE1) and its homolog BACE2 inhibitor (Ki of 2.2 nM and 0.38 nM respectively). It exhibits no inhibition of cathepsin D, cathepsin E, pepsin, or renin. Verubecestat potently reduces Aβ40 formation in HEK293 APPSwe/Lon cells (IC50 = 2.1 nM). Verubecestat significantly lowers CSF and brain Aβ levels in rats. Orally bioavailable.
Compound Libraries for Verubecestat
Verubecestat is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Verubecestat
| M. Wt | 409.41 |
| Formula | C17H17F2N5O3S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1286770-55-5 |
| PubChem ID | 51352361 |
| InChI Key | YHYKUSGACIYRML-KRWDZBQOSA-N |
| Smiles | C[C@@]1(C2=CC(NC(=O)C3=CC=C(F)C=N3)=CC=C2F)CS(=O)(=O)N(C)C(N)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Verubecestat
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.94 | 100 | |
| ethanol | 8.19 | 20 |
Preparing Stock Solutions for Verubecestat
The following data is based on the product molecular weight 409.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.44 mL | 12.21 mL | 24.43 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.89 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.44 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
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Product Datasheets for Verubecestat
References for Verubecestat
References are publications that support the biological activity of the product.
Scott et al (2016) Discovery of the 3-imino-1,2,4-thiadiazinane 1,1-dioxide derivative Verubecestat (MK-8931) - A β-site amyloid precursor protein cleaving enzyme 1 inhibitor for the treatment of Alzheimer's disease. J.Med.Chem. 59 10435 PMID: 27933948
If you know of a relevant reference for Verubecestat, please let us know.
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Keywords: Verubecestat, Verubecestat supplier, potent, selective, inhibitors, inhibits, beta-secretase, BACE1, BACE2, beta, amyloid, Alzheimers, disease, alzheimer's, Other, Proteases, Amyloid, Beta, Peptides, 7659, Tocris Bioscience
Citations for Verubecestat
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