Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewVTP 27999 trifluoroacetate
Description: Highly potent and selective renin inhibitor
Chemical Name: Methyl N-[2-[(R)-(3-Chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]carbamate trifluoroacetate
Purity: ≥97% (HPLC)
Biological Activity for VTP 27999 trifluoroacetate
VTP 27999 trifluoroacetate is a highly potent and selective renin inhibitor (IC50 = 0.47 nM). Displays >1000-fold selectivity over related and unrelated off-targets. Blocks renin-stimulated ERK1/2 phosphorylation in vascular smooth muscle cells. Exhibits a different mode of action to aliskiren (Cat. No. 5491).
Technical Data for VTP 27999 trifluoroacetate
| M. Wt | 639.1 |
| Formula | C26H41ClN4O5.CF3CO2H |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 1013937-63-7 |
| PubChem ID | 121513870 |
| InChI Key | SYWYSVAEGXHOJO-VIEYARBJSA-N |
| Smiles | ClC1=CC=CC([C@H](OCCNC(OC)=O)[C@]2([H])CCCN(C(NC[C@@H](NC)C[C@H]3CCCOC3)=O)C2)=C1.OC(C(F)(F)F)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for VTP 27999 trifluoroacetate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 63.91 | 100 | |
| DMSO | 63.91 | 100 |
Preparing Stock Solutions for VTP 27999 trifluoroacetate
The following data is based on the product molecular weight 639.1. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.56 mL | 7.82 mL | 15.65 mL |
| 5 mM | 0.31 mL | 1.56 mL | 3.13 mL |
| 10 mM | 0.16 mL | 0.78 mL | 1.56 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.31 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for VTP 27999 trifluoroacetate
References for VTP 27999 trifluoroacetate
References are publications that support the biological activity of the product.
Jia et al (2011) Discovery of VTP-27999, an alkyl amine renin inhibitor with potential for clinical utility. ACS Med.Chem.Lett. 2 747 PMID: 24900262
Lu et al (2014) Renin inhibitor VTP-27999 differs from aliskiren: focus on their intracellular accumulation and the (pro)renin receptor. J.Hypertens. 32 1255 PMID: 24637873
If you know of a relevant reference for VTP 27999 trifluoroacetate, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: VTP 27999 trifluoroacetate, VTP 27999 trifluoroacetate supplier, VTP, 27999, trifluoroacetate, highly, potent, selective, renin, inhibitors, inhibits, Other, Proteases, 5563, Tocris Bioscience
Citations for VTP 27999 trifluoroacetate
Citations are publications that use Tocris products.
Currently there are no citations for VTP 27999 trifluoroacetate. Do you know of a great paper that uses VTP 27999 trifluoroacetate from Tocris? Please let us know.
Reviews for VTP 27999 trifluoroacetate
There are currently no reviews for this product. Be the first to review VTP 27999 trifluoroacetate and earn rewards!
Have you used VTP 27999 trifluoroacetate?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image