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Xanthohumol

Cat. No. 4686 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: p97 ATPase (VCP) inhibitor
Chemical Name: (2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Xanthohumol

Xanthohumol is a p97 ATPase (VCP) inhibitor. Binds to the N domain of p97, impairing autophagosome function and maturation. Inhibits proliferation and induces apoptosis in a variety of human cancer cell lines. Also inhibits DGAT in rat liver microsomes (IC50 = 50.3 μM).

Compound Libraries for Xanthohumol

Xanthohumol is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Xanthohumol

M. Wt 354.4
Formula C21H22O5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 6754-58-1
PubChem ID 639665
InChI Key ORXQGKIUCDPEAJ-YRNVUSSQSA-N
Smiles OC1=C(C(/C=C/C2=CC=C(O)C=C2)=O)C(OC)=CC(O)=C1C/C=C(C)/C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Xanthohumol

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.44 100
ethanol 35.44 100

Preparing Stock Solutions for Xanthohumol

The following data is based on the product molecular weight 354.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.11 mL 28.22 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets for Xanthohumol

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Xanthohumol

References are publications that support the biological activity of the product.

Sasazawa et al (2012) Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein. ACS Chem.Biol. 7 892 PMID: 22360440

Tabata et al (1997) Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus. Phytochemistry 46 683 PMID: 9366096

Inokoshi et al (2009) Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes. J.Antibiot.(Tokyo) 62 51 PMID: 19132064

If you know of a relevant reference for Xanthohumol, please let us know.

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Keywords: Xanthohumol, Xanthohumol supplier, valosin-containing, protein, VCP, transitional, endoplasmic, reticulum, ATPase, TER, inhibitors, autophagosome, autophagy, apoptosis, inhibits, Autophagy, Diacylglycerol, O-Acyltransferase, Other, ER, stress/UPR, p97, 4686, Tocris Bioscience

2 Citations for Xanthohumol

Citations are publications that use Tocris products. Selected citations for Xanthohumol include:

Muthusamy et al (2017) Antiproliferative and apoptotic effects of xanthohumol in cholangiocarcinoma. Oncotarget 8 88069-88078 PMID: 29152142

den Brok et al (2016) Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation Nature Communications 7 13324 PMID: 27819292

Do you know of a great paper that uses Xanthohumol from Tocris? Please let us know.

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Literature in this Area

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