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Description: Fluorescein labeled XIAP ligand for TR-FRET assay development
Purity: ≥95% (HPLC)
Biological Activity for XIAP Tracer mF-Smac
XIAP Tracer mF-Smac is a fluorescent labeled peptide used as an acceptor dye with a terbium labeled BIR domain antibody in TR-FRET assays (Kd values are 4.7 nM at BIR3 (XIAP); 17.9 nM in XIAP polarization assay).
Optical Data for XIAP Tracer mF-Smac
| Emission Color | Near-IR |
|---|---|
| λabs | 485 nm |
| λem | 520 nm |
| Closest Laser line | 488 nm |
| Application | Fluorescence polarization (FP), Time-resolved fluorescence energy transfer (TR-FRET) |
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
Spectral Viewer
Technical Data for XIAP Tracer mF-Smac
| M. Wt | 989.1 |
| Formula | C51H60N10O11 |
| Sequence |
XRPFK (Modifications: X-1 = 2-Aminobutanoic acid, Lys-5 = Lys(5-FAM), Lys-5 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 783340-88-5 |
| InChI Key | ONHYLEJPWIONKB-HECCNADXSA-N |
| Smiles | CC[C@H](N)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N)=O)CCCCNC(C2=CC=C3C(C(OC34C5=CC=C(O)C=C5OC6=CC(O)=CC=C64)=O)=C2)=O)=O)CC7=CC=CC=C7)=O)=O)CCCNC(N)=N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for XIAP Tracer mF-Smac
| Solubility | Soluble to 2 mg/ml in 25% ethanol / water |
Product Datasheets for XIAP Tracer mF-Smac
References for XIAP Tracer mF-Smac
References are publications that support the biological activity of the product.
Chaudhry et al (2016) Building homogeneous time-resolved fluorescence resonance energy transfer assays for characterization of bivalent inhibitors of an inhibitor of apoptosis protein target. Anal.Biochem. 497 8 PMID: 26743718
If you know of a relevant reference for XIAP Tracer mF-Smac, please let us know.
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Citations for XIAP Tracer mF-Smac
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for XIAP Tracer mF-Smac
