10Z-Hymenialdisine

Name: 10 Z -Hymenialdisine
Brand: Tocris Bioscience
SKU: 1532

Cat. No. 1532 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1532 has been discontinued.

View all Broad Spectrum Protein Kinase Inhibitors products.

说明： Broad spectrum protein kinase inhibitor

别名： SK&F 108752

化学名： (4Z)-4-(2-Amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one

纯度： ≥97% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for 10Z-Hymenialdisine

Pan kinase inhibitor (IC₅₀ values are 6, 10, 22, 28, 35, 40, 70, 80, 100, 470, 500, 600, 700 and 700 nM for MEK1, GSK-3β, Cdk1/cyclin B, Cdk5/p25, CK1, Cdk2/cyclin A, Cdk2/cyclin E, ASK-γ, Cdk3/cyclin E, Erk1, PKCγ, Cdk4/cyclin D1, Cdk6/cyclin D2 and PKCα respectively.) Inhibits NF-κB activation and blocks IL-8 production in U937 cells (IC₅₀ values are 1-2 and 0.34-0.48 μM respectively).

技术数据 for 10Z-Hymenialdisine

分子量	324.13
公式	C₁₁H₁₀BrN₅O₂
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	82005-12-7
PubChem ID	3035462
InChI Key	ATBAETXFFCOZOY-DAXSKMNVSA-N
Smiles	O=C(NCC1)C2=C(C=C(Br)N2)/C1=C3/C(N=C(N)N3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for 10Z-Hymenialdisine

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 10Z-Hymenialdisine

参考文献是支持产品生物活性的出版物。

Tasdemir et al (2002) Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). J.Med.Chem. 45 529 PMID: 11784156

Meijer et al (2000) Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituent. Chem.Biol. 7 51 PMID: 10662688

Breton and Chabot-Fletcher (1997) The natural product hymenialdisine inhibits interleukin-8 production in U937 cells by inhibition of nuclear factor-κB. J.Pharmacol.Exp.Ther. 282 459 PMID: 9223588

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987

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关键词: 10Z-Hymenialdisine, 10Z-Hymenialdisine supplier, SK&F108752, potent, pan, kinase, inhibitors, inhibits, CK1, Cdk, GSK-3beta, GSK-3b, cyclin, Erk1, MEK-1, MEK1, PKC, NF-kB, NF-kappaB, activation, IL-8, production, anti-inflammatory, SK&F, 108752, Broad, Spectrum, Protein, Kinase, Inhibitors, 1532, Tocris Bioscience

篇 10Z-Hymenialdisine 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 10Z-Hymenialdisine 的引用文献。