Home / Pharmacology / Enzymes / Kinases / DNA-Dependent Protein Kinase / DNA-Dependent Protein Kinase Inhibitors / LTURM 34

LTURM 34

Cat. No. 5834 Submit a Review Datasheet / COA / SDS
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Description: Potent DNA-PK inhibitor; also increases CRISPR-Cas9 deletion efficiency
Chemical Name: 8-(4-Dibenzothienyll)-2-(4-morpholinyl)-4H-1,3-benzoxazin-4-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for LTURM 34

LTURM 34 is a potent DNA-PK inhibitor (IC50 = 34 nM). Exhibits 170-fold selectivity for DNA-PK over PI3-K. Attenuates proliferation of a wide range of tumor cell lines in vitro. LTURM 34 also increases CRISPR-Cas9 deletion efficiency.

Technical Data for LTURM 34

M. Wt 414.48
Formula C24H18N2O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1879887-96-3
PubChem ID 122705987
InChI Key SMMSWOMXOZLOPI-UHFFFAOYSA-N
Smiles O=C1C2=C(C(C3=CC=CC4=C3SC5=C4C=CC=C5)=CC=C2)OC(N6CCOCC6)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LTURM 34

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.72 50

Preparing Stock Solutions for LTURM 34

The following data is based on the product molecular weight 414.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.83 mL 24.13 mL 48.25 mL
2.5 mM 0.97 mL 4.83 mL 9.65 mL
5 mM 0.48 mL 2.41 mL 4.83 mL
25 mM 0.1 mL 0.48 mL 0.97 mL

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Product Datasheets for LTURM 34

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for LTURM 34

References are publications that support the biological activity of the product.

Morrison et al (2016) Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur.J.Med.Chem. 110 326 PMID: 26854431

Bosch-Guiteras et al (2021) Enhancing CRISPR deletion via pharmacological delay of DNA-PKcs. Genome Res. 31 461 PMID: 33574136

If you know of a relevant reference for LTURM 34, please let us know.

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Keywords: LTURM 34, LTURM 34 supplier, LTURM34, potent, DNA-PK, inhibitors, inhibits, DNA-dependent, protein, kinases, HDR, homology-directed, repair, CRISPR, cas9, reagents, Protein, Kinase, Reagents, 5834, Tocris Bioscience

Citations for LTURM 34

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Literature in this Area

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