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说明： Potent Lys-covalent pan-IAP inhibitor

化学名： (R)-1-((S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamido)-2,3-dihydro-1H-inden-4-yl sulfurofluoridate

纯度： ≥95% (HPLC)

说明书

引用文献

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生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 142D6

142D6 is a potent pan-IAP inhibitor (IC₅₀ values are 21, 21 and 43 nM for cIAP1, cIAP2 and XIAP respectively). 142D6 covalently targets Lys residues in the BIR3 domain of the inhibitor of the apoptosis protein (IAP) family. In vitro, 142D6 reduces viability of cultured breast cancer MDA-MB-231 cells (EC₅₀values are 44 and 61 nM in cell viability and apoptosis assays, respectively). 142D6 is chemically stable in buffer and plasma and is orally bioavailable.

许可信息

Sold under patent license from The Regents of the University of California

技术数据 for 142D6

分子量	552.66
公式	C₂₆H₃₇FN₄O₆S
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	2410953-19-2
InChI Key	YVERFLKIJOIKPE-HXGJMTJLSA-N
Smiles	O=C([C@H]1N(CCC1)C([C@H](C2CCCCC2)NC([C@H](C)NC)=O)=O)N[C@H]3C4=CC=CC(OS(F)(=O)=O)=C4CC3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 142D6

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	55.27	100

制备储备液 for 142D6

以下数据基于产品分子量 552.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.81 mL	9.05 mL	18.09 mL
5 mM	0.36 mL	1.81 mL	3.62 mL
10 mM	0.18 mL	0.9 mL	1.81 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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产品说明书 for 142D6

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参考文献 for 142D6

参考文献是支持产品生物活性的出版物。

Baggio et al (2019) Aryl-fluorosulfate-based lysine covalent pan-inhibitors of apoptosis protein (IAP) antagonists with cellular efficacy. J.Med.Chem. 62 9188 PMID: 31550155

Udompholkul et al (2023) Characterization of a potent and orally bioavailable Lys-covalent inhibitor of apoptosis protein (IAP) antagonist. J.Med.Chem. 66 8159 PMID: 37262387

If you know of a relevant reference for 142D6, please let us know.

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关键词: 142D6, 142D6 supplier, XIAP, cIAP1, cIAP2, BIR3, domain, antagonist, potent, antagonism, inhibitors, inhibits, inhibitor, of, apoptosis, IAP, breast, cancer, Inhibitor, Apoptosis, (IAP), 8018, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for 142D6

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

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