1M7

Cat. No. 6602 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Reagent for RNA SHAPE-MaP chemistry

别名： 1-Methyl-7-nitroisatoic anhydride

化学名： 1-Methyl-7-nitro-2H-3,1-benzoxazine-2,4(1H)-dione

纯度： ≥95% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 1M7

1M7 is a reagent for RNA SHAPE-MaP experiments. Enables analysis of RNA secondary structures at single nucleotide resolution in <70 seconds.

技术数据 for 1M7

分子量	222.15
公式	C₉H₆N₂O₅
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	73043-80-8
PubChem ID	12535373
InChI Key	MULNCJWAVSDEKJ-UHFFFAOYSA-N
Smiles	CN1C(OC(C2=CC=C([N+]([O-])=O)C=C12)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 1M7

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	22.21	100

制备储备液 for 1M7

以下数据基于产品分子量 222.15。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	4.5 mL	22.51 mL	45.01 mL
5 mM	0.9 mL	4.5 mL	9 mL
10 mM	0.45 mL	2.25 mL	4.5 mL
50 mM	0.09 mL	0.45 mL	0.9 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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产品说明书 for 1M7

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 1M7

参考文献是支持产品生物活性的出版物。

Mortimer et al (2007) A fast-acting reagent for accurate analysis of RNA secondary and tertiary structure by SHAPE chemistry. J.Am.Chem.Soc. 129 4144 PMID: 17367143

Turner et al (2013) Safer one-pot synthesis of the 'SHAPE' reagent 1-methyl-7-nitroisatoic anhydride (1m7). RNA 19 1857 PMID: 24141619

Siegfried et al (2014) RNA motif discovery by SHAPE and mutational profiling (SHAPE-MaP). Nat.Methods 11 959 PMID: 25028896

Smola et al (2015) Detection of RNA-Protein interactions in living cells with SHAPE. Biochemistry 54 6867 PMID: 26544910

If you know of a relevant reference for 1M7, please let us know.

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关键词: 1M7, 1M7 supplier, Reagent, RNA, SHAPE, MaP, chemistry, experiments, 1methyl7nitroisatoic, mapping, secondary, tertiary, structures, 1-methyl-7-nitroisatoic, anhydride, DNA,, and, Protein, Synthesis, Biochemicals, Molecular, Biology, 6602, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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1M7