2,3-DCPE hydrochloride

Cat. No. 2137 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selectively induces cancer cell apoptosis

化学名： 2-[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol hydrochloride

纯度： ≥99% (HPLC)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 2,3-DCPE hydrochloride

2,3-DCPE hydrochloride is a selectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro. IC₅₀ values are 0.89 and 12.6 μM for LoVo human colon cancer cell line and normal human fibroblasts respectively. Induces p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways.

技术数据 for 2,3-DCPE hydrochloride

分子量	300.61
公式	C₁₁H₁₅Cl₂NO₂.HCl
储存	Desiccate at -20°C
纯度	≥99% (HPLC)
CAS Number	1009555-55-8
PubChem ID	52913859
InChI Key	GFCJFYSIPRIHKT-UHFFFAOYSA-N
Smiles	Cl.OCCNCCCOC1=C(Cl)C(Cl)=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 2,3-DCPE hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	30.06	100

制备储备液 for 2,3-DCPE hydrochloride

以下数据基于产品分子量 300.61。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.33 mL	16.63 mL	33.27 mL
5 mM	0.67 mL	3.33 mL	6.65 mL
10 mM	0.33 mL	1.66 mL	3.33 mL
50 mM	0.07 mL	0.33 mL	0.67 mL

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产品说明书 for 2,3-DCPE hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 2,3-DCPE hydrochloride

参考文献是支持产品生物活性的出版物。

Wu et al (2004) Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol. Cancer Res. 64 1110 PMID: 14871845

Zhu et al (2004) Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol in correlation with activation of ERK. Oncogene 23 4984 PMID: 15122344

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Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for 2,3-DCPE hydrochloride

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.