Apoptosis Inducers
Apoptosis inducers exhibit pro-apoptotic effects through a variety of mechanisms, including DNA cross-linking, inhibition of antiapoptotic proteins and activation of caspases. These inducers may target a specific cellular process in order to induce antitumor or antineoplastic effects.
| Cat. No. | 产品名称/活性 |
|---|---|
| 1229 | Actinomycin D |
| Antineoplastic antibiotic | |
| 2098 | Apoptosis Activator 2 |
| Selectively induces tumor cell apoptosis | |
| 3367 | AT 101 |
| Downregulates Bcl-2 and Mcl-1; pro-apoptotic | |
| 3681 | Bendamustine hydrochloride |
| Cytostatic agent; exhibits DNA alkylating and purine analog properties | |
| 3906 | Betulinic acid |
| Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist | |
| 5791 | Bz 423 |
| ATP synthase inhibitor; proapoptotic | |
| 2489 | C 75 |
| Induces apoptosis and exhibits anti-tumor activity | |
| 2626 | Carboplatin |
| DNA cross-linking antitumor agent | |
| 2251 | Cisplatin |
| DNA-alkylating antitumor agent | |
| 5292 | Cladribine |
| Deoxyadenosine analog; pro-apoptotic | |
| 4091 | Cyclophosphamide |
| Alkylating agent; chemotherapeutic | |
| 2137 | 2,3-DCPE hydrochloride |
| Selectively induces cancer cell apoptosis | |
| 2252 | Doxorubicin hydrochloride |
| Antitumor antibiotic agent; induces apoptosis | |
| 7507 | Evofosfamide |
| Hypoxia-activated DNA alkylating agent prodrug | |
| 8072 | FK 866 |
| Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy | |
| 3495 | Fludarabine |
| Proapoptotic; increases Bax and decreases Bid, XIAP and survivin expression | |
| 6776 | G5 |
| Activates apoptosis in an apoptosome-independent pathway; ubiquitin isopeptidase inhibitor | |
| 3603 | Kaempferol |
| Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter | |
| 6617 | LYN 1604 dihydrochloride |
| Induces apoptosis; ULK1 agonist | |
| 3258 | Mitomycin C |
| DNA cross-linking antitumor agent | |
| 3715 | Narciclasine |
| Antiproliferative agent; exhibits pro-apoptotic effects | |
| 2623 | Oxaliplatin |
| DNA cross-linking antitumor agent | |
| 4643 | PCI 34051 |
| Potent and selective histone deacetylase 8 (HDAC8) inhibitor; induces apoptosis in T cell-derived cell lines | |
| 5314 | SMBA 1 |
| High affinity and selective activator of Bax | |
| 1621 | Streptozocin |
| DNA alkylator; antitumor and induces diabetes | |
| 2706 | Temozolomide |
| DNA-methylating antitumor agent |
Literature for Apoptosis Inducers
Tocris offers the following scientific literature for Apoptosis Inducers to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for Apoptosis Inducers
Apoptosis Signaling Pathway
Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.Written by Bram van Raam and Guy Salvesen
Our Programmed Cell Death poster gives a summary of the signaling pathways involved in apoptosis, necroptosis and cell survival.
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