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Submit Review2-Methoxyestradiol
说明： Apoptotic and antiangiogenic agent
化学名： (17β)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol
纯度： ≥99% (HPLC)
生物活性 for 2-Methoxyestradiol
2-Methoxyestradiol is an apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.
技术数据 for 2-Methoxyestradiol
| 分子量 | 302.41 |
| 公式 | C19H26O3 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 362-07-2 |
| PubChem ID | 66414 |
| InChI Key | CQOQDQWUFQDJMK-SSTWWWIQSA-N |
| Smiles | OC1=C(OC)C=C2C(CC[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for 2-Methoxyestradiol
参考文献 for 2-Methoxyestradiol
参考文献是支持产品生物活性的出版物。
D'Amato et al (1994) 2-MethoxyOE, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colch. site. Proc.Natl.Acad.Sci.U.S.A. 91 3964 PMID: 8171020
LaVallee et al (2002) 2-MethoxyOE inhibits proliferation and induces apoptosis independently of estrogen receptors α and β. Cancer Res. 62 3691 PMID: 12097276
LaVallee et al (2003) 2-MethoxyOE up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway. Cancer Res. 63 468 PMID: 12543804
Shimada et al (2003) Roles of p38 and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyOE-induced p53 induction and apoptosis. Carcinogenesis 24 1067 PMID: 12807754
关键词: 2-Methoxyestradiol, 2-Methoxyestradiol supplier, Apoptotic, agent, Apoptosis, Inducer, Antiangiogenics, Inducers, 1807, Tocris Bioscience
1 篇 2-Methoxyestradiol 的引用文献
引用文献是使用了 Tocris 产品的出版物。 2-Methoxyestradiol 的部分引用包括：
Valencia-Cervantes et al (2019) Hypoxia increases chemoresistance in human medulloblastoma DAOY cells via hypoxia-inducible factor 1α-mediated downregulation of the CYP2B6, CYP3A4 and CYP3A5 enzymes and inhibition of cell proliferation. Oncol Rep 41 178 PMID: 30320358
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Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for 2-Methoxyestradiol
