2R,6R-Hydroxynorketamine hydrochloride

Pricing Availability   Qty
说明: Enhances AMPA currents; decreases D-serine (a NMDA co-agonist); lacks ketamine-related side effects
化学名: (2R,6R)-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
纯度: ≥98% (HPLC)
说明书
引用文献 (10)
评论
文献 (2)

生物活性 for 2R,6R-Hydroxynorketamine hydrochloride

2R,6R-Hydroxynorketamine hydrochloride is a ketamine metabolite. It enhances AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices and decreases intracellular D-serine (a NMDA co-agonist) concentrations in PC-12 cells (IC50 = 0.68 nM). 2R,6R-Hydroxynorketamine upregulates KCNQ2 channels in mouse ventral hippocampal glutamatergic neurons in vitro and in vivo. Exerts antidepressant effects in mice. Lacks ketamine-related side effects.

2S,6S-Enantiomer and Racemate also available.

许可信息

Sold under license from the NIH, US patent 62/313,309

技术数据 for 2R,6R-Hydroxynorketamine hydrochloride

分子量 276.16
公式 C12H14ClNO2.HCl
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 1430202-69-9
PubChem ID 121513910
InChI Key ZQJVHBJDLMIKJK-MHDYBILJSA-N
Smiles ClC1=C([C@@]2(N)C([C@H](O)CCC2)=O)C=CC=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 2R,6R-Hydroxynorketamine hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 13.81 50
DMSO 27.62 100

制备储备液 for 2R,6R-Hydroxynorketamine hydrochloride

以下数据基于产品分子量 276.16。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.62 mL 18.11 mL 36.21 mL
5 mM 0.72 mL 3.62 mL 7.24 mL
10 mM 0.36 mL 1.81 mL 3.62 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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产品说明书 for 2R,6R-Hydroxynorketamine hydrochloride

分析证书/产品说明书
选择另一批次:

参考文献 for 2R,6R-Hydroxynorketamine hydrochloride

参考文献是支持产品生物活性的出版物。

Singh et al (2016) KA metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells. PLoS One 11 e0149499 PMID: 27096720

Zanos et al (2016) NMDAR inhibition-independent antidepressant actions of KA metabolites. Nature 533 481 PMID: 27144355

Lopez et al (2022) Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2. Neuron 110 2283 PMID: 35649415


If you know of a relevant reference for 2R,6R-Hydroxynorketamine hydrochloride, please let us know.

关键词: 2R,6R-Hydroxynorketamine hydrochloride, 2R,6R-Hydroxynorketamine hydrochloride supplier, Potent, AMPA, agonists, agonism, ketamine, metabolites, antidepressants, enantiomer, APJ, 2R,6R-HNK, depression, Receptors, Ketamine, and, Metabolites, 6094, Tocris Bioscience

10 篇 2R,6R-Hydroxynorketamine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 2R,6R-Hydroxynorketamine hydrochloride 的部分引用包括:

Eero et al (2019) Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2. J Biol Chem 294 18150-18161 PMID: 31631060

Ago et al (2019) (R)-Ketamine induces a greater increase in prefrontal 5-HT release than (S)-Ketamine and Ketamine Metabolites via an AMPA receptor-independent mechanism. Int J Neuropsychopharmacol 22 665 PMID: 31325908

Ye et al (2019) KA metabolite (2R,6R)-hydroxynorKA enhances aggression via periaqueductal gray glutamatergic transmission. Neuropharmacology 157 PMID: 31207251

Plinio C et al (2023) Ketamine and its metabolite 2R,6R-hydroxynorketamine promote ocular dominance plasticity and release tropomyosin-related kinase B from inhibitory control without reducing perineuronal nets enwrapping parvalbumin interneurons. Eur J Neurosci 57 940-950 PMID: 36740723


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