主页 / Product Type / Reagents / Ketamine and Metabolites / 2S,6S-Hydroxynorketamine hydrochloride

2S,6S-Hydroxynorketamine hydrochloride

Cat. No. 6095 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Decreases D-serine (a NMDA co-agonist); antidepressant
化学名： (2S,6S)-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (4)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 2S,6S-Hydroxynorketamine hydrochloride

2S,6S-Hydroxynorketamine hydrochloride is a ketamine metabolite. Decreases intracellular D-serine (a NMDA co-agonist) concentrations in PC-12 cells (IC50 = 0.18 nM). Exerts antidepressant effects in mice.

2R,6R-Enantiomer and Racemate also available.

许可信息

Sold under license from the NIH, US patent 62/313,309

技术数据 for 2S,6S-Hydroxynorketamine hydrochloride

分子量 276.16
公式 C12H14ClNO2.HCl
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 1430202-70-2
PubChem ID 124201855
InChI Key ZQJVHBJDLMIKJK-JGAZGGJJSA-N
Smiles ClC1=C([C@]2(N)C([C@@H](O)CCC2)=O)C=CC=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 2S,6S-Hydroxynorketamine hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 13.81 50
DMSO 27.62 100

制备储备液 for 2S,6S-Hydroxynorketamine hydrochloride

以下数据基于产品分子量 276.16。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.62 mL 18.11 mL 36.21 mL
5 mM 0.72 mL 3.62 mL 7.24 mL
10 mM 0.36 mL 1.81 mL 3.62 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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产品说明书 for 2S,6S-Hydroxynorketamine hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for 2S,6S-Hydroxynorketamine hydrochloride

参考文献是支持产品生物活性的出版物。

Singh et al (2016) KA metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells. PLoS One 11 e0149499 PMID: 27096720

Zanos et al (2016) NMDAR inhibition-independent antidepressant actions of KA metabolites. Nature 533 481 PMID: 27144355

If you know of a relevant reference for 2S,6S-Hydroxynorketamine hydrochloride, please let us know.

按标靶查看相关产品

关键词: 2S,6S-Hydroxynorketamine hydrochloride, 2S,6S-Hydroxynorketamine hydrochloride supplier, Potent, AMPA, agonists, agonism, ketamine, metabolites, antidepressants, enantiomer, 2S,6S-HNK, depression, Receptors, NMDA, Ketamine, and, Metabolites, 6095, Tocris Bioscience

4 篇 2S,6S-Hydroxynorketamine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 2S,6S-Hydroxynorketamine hydrochloride 的部分引用包括：

Ago et al (2019) (R)-Ketamine induces a greater increase in prefrontal 5-HT release than (S)-Ketamine and Ketamine Metabolites via an AMPA receptor-independent mechanism. Int J Neuropsychopharmacol 22 665 PMID: 31325908

Ye et al (2019) KA metabolite (2R,6R)-hydroxynorKA enhances aggression via periaqueductal gray glutamatergic transmission. Neuropharmacology 157 PMID: 31207251

Eero et al (2022) Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro. Front Pharmacol 12 755600 PMID: 35126106

Chou et al (2018) (2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray. Neuropharmacology 139 1 PMID: 29953886

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