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说明： PFKFB3 inhibitor
化学名： 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one
纯度： ≥99% (HPLC)
生物活性 for 3PO
3PO is originally reported to inhibit PFKFB3 (IC50 = 25 μM). More recent reports failed to demonstrate activity in a PFKFB3 kinase assay. Reduces glycolytic flux and suppresses glucose uptake. Inhibits endothelial cell proliferation and causes G2/M cell cycle arrest in vitro. Attenuates vessel sprouting and tumor growth in vivo. Amplifies the antiangiogenic effect of VEGFR blockade.
技术数据 for 3PO
| 分子量 | 210.23 |
| 公式 | C13H10N2O |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 13309-08-5 |
| PubChem ID | 5720233 |
| InChI Key | UOWGYMNWMDNSTL-ONEGZZNKSA-N |
| Smiles | O=C(/C=C/C2=CN=CC=C2)C1=CC=NC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for 3PO
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 21.02 | 100 |
制备储备液 for 3PO
以下数据基于产品分子量 210.23。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.76 mL | 23.78 mL | 47.57 mL |
| 5 mM | 0.95 mL | 4.76 mL | 9.51 mL |
| 10 mM | 0.48 mL | 2.38 mL | 4.76 mL |
| 50 mM | 0.1 mL | 0.48 mL | 0.95 mL |
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产品说明书 for 3PO
参考文献 for 3PO
参考文献是支持产品生物活性的出版物。
Clem et al (2008) Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol.Cancer Ther. 7 110 PMID: 18202014
Schoors et al (2014) Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. Cell Metab. 19 37 PMID: 24332967
Boyd et al (2015) Structure-based design of potent and selective inhibitors of the metabolic kinase PFKFB3. J.Med.Chem. 58 3611 PMID: 25849762
If you know of a relevant reference for 3PO, please let us know.
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关键词: 3PO, 3PO supplier, PFKFB3, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, inhibitors, inhibits, glycolysis, antitumor, antitumour, antiangiogenic, Antiangiogenics, 5121, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cancer Metabolism Research Product Guide
This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:
- Glycolysis
- Tricarboxylic Acid Cycle
- Lipidogenesis
- 1C Metabolism and Nucleic Acid Synthesis
- Drivers of Metabolic Reprogramming
- pH and Redox Balance
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.