5-Iodotubercidin

Cat. No. 1745 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases

化学名： 5-Iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

纯度： ≥97% (HPLC)

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 5-Iodotubercidin

5-Iodotubercidin is a potent adenosine kinase inhibitor (IC₅₀ = 26 nM). Also nucleoside transporter inhibitor (IC₅₀ values are < 25 nM, 7 μM and 15 μM for inhibition of [³H]adenosine, [³H]uridine and [³H]formycin B uptake respectively). Strongly stimulates glycogen synthesis in hepatocytes via activation of glycogen synthase. Also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC (IC₅₀ values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 μM respectively). Decreases hippocampal DNA methylation through adenosine kinase inhibition in vivo.

技术数据 for 5-Iodotubercidin

分子量	392.15
公式	C₁₁H₁₃IN₄O₄
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	24386-93-4
PubChem ID	97297
InChI Key	WHSIXKUPQCKWBY-IOSLPCCCSA-N
Smiles	O[C@H]([C@H](O)[C@@H](CO)O3)[C@@H]3N1C2=C(C(N)=NC=N2)C(I)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 5-Iodotubercidin

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	19.61	50

制备储备液 for 5-Iodotubercidin

以下数据基于产品分子量 392.15。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	5.1 mL	25.5 mL	51 mL
2.5 mM	1.02 mL	5.1 mL	10.2 mL
5 mM	0.51 mL	2.55 mL	5.1 mL
25 mM	0.1 mL	0.51 mL	1.02 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for 5-Iodotubercidin

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 5-Iodotubercidin

参考文献是支持产品生物活性的出版物。

Massillon et al (1994) Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor. Biochem.J. 299 123 PMID: 8166629

Parkinson and Geiger (1996) Effects of iodotubercidin on adenosine kinase activity and nucleoside transport in DDT₁ MF-2 smooth muscle cells. J.Pharmacol.Exp.Ther. 277 1397 PMID: 8667202

Ugarkar et al (2000) Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues. J.Med.Chem. 43 2883 PMID: 10956196

Williams-Karnesky et al (2013) Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis. J.Clin.Invest. 123 3552 PMID: 23863710

If you know of a relevant reference for 5-Iodotubercidin, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Adeonsine Kinase Inhibitors

关键词: 5-Iodotubercidin, 5-Iodotubercidin supplier, Potent, adenosines, kinase, inhibitors, nucleoside, transporters, ENT1, reuptake, Purine, Transporters, Pyrimidine, Equilibrative, Monoamine, Neurotransmitter, ADK, 5-it, inhibits, DNA, methylation, Adenosine, Kinase, Broad, Spectrum, Protein, Inhibitors, Nucleoside, Other, Methyltransferases, 1745, Tocris Bioscience