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5-Ph-IAA-AM

Cat. No. 7893 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective and potent TAG Degrader for auxin-inducible degron 2 system; 5-Ph-IAA analog
化学名： Acetoxymethyl 2-(5-phenyl-1H-indol-3-yl)acetate
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 5-Ph-IAA-AM

5-Ph-IAA-AM is a potent and selective "Bump & Hole" TAG Degrader, for use within an auxin-inducible degron (AID2) system; it is an egg-permeant analog of 5-Ph-IAA (Cat. No. 7392). 5-Ph-IAA-AM induces selective degradation of a target protein tagged with a single-point mutant AtTIR1F79G F-box protein. 5-Ph-IAA-AM induces target protein degradation in C. elegans embryos. No developmental abnormality is observed when the embryos are treated with 50 μM 5-Ph-IAA-AM.

技术数据 for 5-Ph-IAA-AM

分子量 323.35
公式 C19H17NO4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2990123-10-7
PubChem ID 162641049
InChI Key FGVMSTLYCNILJO-UHFFFAOYSA-N
Smiles O=C(OCOC(C)=O)CC1=CNC2=C1C=C(C=C2)C3=CC=CC=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 5-Ph-IAA-AM

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 32.34 100
ethanol 3.23 10

制备储备液 for 5-Ph-IAA-AM

以下数据基于产品分子量 323.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.09 mL 15.46 mL 30.93 mL
5 mM 0.62 mL 3.09 mL 6.19 mL
10 mM 0.31 mL 1.55 mL 3.09 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Molarity Calculator

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Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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参考文献 for 5-Ph-IAA-AM

参考文献是支持产品生物活性的出版物。

Negishi et al (2022) The auxin-inducible degron 2 (AID2) system enables controlled protein knockdown during embryogenesis and development in Caenorhabditis elegans. Genetics 220 iyab218 PMID: 34865044

If you know of a relevant reference for 5-Ph-IAA-AM, please let us know.

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关键词: 5-Ph-IAA-AM, 5-Ph-IAA-AM supplier, auxin-inducible, degron, AID2, AID, TAG, Degrades, Degraders, degradation, target, fusion, protein, mAID, 5-Ph-IAA, Degradation, Platform, 7893, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia

Validating Targets for TPD Using dTAG Poster

Validating Targets for TPD Using dTAG Poster

The dTAG platform offers a generalizable strategy to degrade, in principle, any intracellular protein of interest (POI) and is a useful strategy for exploration and validation of targets. This poster presents a workflow solution for target validation, from custom TAG knock-in cell-lines for your POI, different dTAG Degraders to knockdown you POI, to automated assays for protein degradation using Simple WesternTM instruments. Data are also presented on the use of an antibody that recognizes the TAG domain (FKBP12F36V) for detection of degradation. Presented at TPD Europe, March 2022, London, UK.