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A 484954

Cat. No. 4483 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： CaM kinase III (eEF-2 kinase) inhibitor
化学名： 7-Amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for A 484954

A 484954 is an inhibitor of eukaryotic elongation factor-2 (eEF-2) kinase (IC50 = 0.28 μM in enzymatic assay). Reduces eEF-2 phosphorylation with little effect on cancer cell growth.

技术数据 for A 484954

分子量 289.29
公式 C13H15N5O3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 142557-61-7
PubChem ID 14998470
InChI Key HWODCHXORCTEGU-UHFFFAOYSA-N
Smiles O=C(N(C3CC3)C2=C1C=C(C(N)=O)C(N)=N2)N(CC)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for A 484954

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 2.89 10

制备储备液 for A 484954

以下数据基于产品分子量 289.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 34.57 mL 172.84 mL 345.67 mL
0.5 mM 6.91 mL 34.57 mL 69.13 mL
1 mM 3.46 mL 17.28 mL 34.57 mL
5 mM 0.69 mL 3.46 mL 6.91 mL

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参考文献 for A 484954

参考文献是支持产品生物活性的出版物。

Chen et al (2011) 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J.Biol.Chem. 286 43951 PMID: 22020937

If you know of a relevant reference for A 484954, please let us know.

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关键词: A 484954, A 484954 supplier, A484954, eukaryotic, elongation, factor-2, kinase, eef2k, inhibitors, inhibits, CaM, Kinase, 4483, Tocris Bioscience

2 篇 A 484954 的引用文献

引用文献是使用了 Tocris 产品的出版物。 A 484954 的部分引用包括：

Bouhaddou et al (2020) The Global Phosphorylation Landscape of SARS-CoV-2 Infection Cell 182 685 PMID: 32645325

Pedro R et al (2022) eEF2K Activity Determines Synergy to Cotreatment of Cancer Cells With PI3K and MEK Inhibitors. Mol Cell Proteomics 21 100240 PMID: 35513296

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