ABT 702 hydrochloride

Cat. No. 2372 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Adenosine kinase inhibitor; orally active

化学名： 5-(3-Bromophenyl)-7-[6-(4-morpholinyl)-3-pyrido[2,3-d]byrimidin-4-amine hydrochloride

纯度： ≥98% (HPLC)

引用文献 (3)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ABT 702 hydrochloride

ABT 702 hydrochloride is a potent non-nucleoside adenosine kinase inhibitor (IC₅₀ = 1.7 nM), selective over other sites of adenosine interaction (A₁, A_2A and A₃ receptors, adenosine transporter and adenosine deaminase). Displays oral activity in animal models of pain and inflammation.

技术数据 for ABT 702 hydrochloride

分子量	499.79
公式	C₂₂H₁₉N₆OBr.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2624336-92-9
PubChem ID	16760265
InChI Key	KXHYOZCVILMBFV-UHFFFAOYSA-N
Smiles	NC1=C2C(N=C(C3=CN=C(N4CCOCC4)C=C3)C=C2C5=CC(Br)=CC=C5)=NC=N1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ABT 702 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	53.66	100

制备储备液 for ABT 702 hydrochloride

以下数据基于产品分子量 499.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2 mL	10 mL	20.01 mL
5 mM	0.4 mL	2 mL	4 mL
10 mM	0.2 mL	1 mL	2 mL
50 mM	0.04 mL	0.2 mL	0.4 mL

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产品说明书 for ABT 702 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ABT 702 hydrochloride

参考文献是支持产品生物活性的出版物。

Jarvis et al (2000) ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I In vitro characterization and acute antinociceptive J.Pharmacol.Exp.Ther. 295 1156 PMID: 11082453

Kowaluk et al (2000) ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties II. In vivo characterization in the rat. J.Pharmacol.Exp.Ther. 295 1165 PMID: 11082454

Lee et al (2001) Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor. J.Med.Chem. 44 2133 PMID: 11405650

If you know of a relevant reference for ABT 702 hydrochloride, please let us know.

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关键词: ABT 702 hydrochloride, ABT 702 hydrochloride supplier, adenosines, kinases, inhibitors, inhibits, orally, active, ADK, Receptors, ABT702, hydrochloride, Adenosine, Kinase, Other, 2372, Tocris Bioscience

3 篇 ABT 702 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ABT 702 hydrochloride 的部分引用包括：

Ahwazi et al (2021) Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965. Biochem J 478 2977 PMID: 34259310

Hobson et al (2012) Stimulation of adenosine receptors in the nucleus accumbens reverses the expression of cocaine sensitization and cross-sensitization to DA D2 receptors in rats. Neuropharmacology 63 1172 PMID: 22749927

Fassett et al (2011) Adenosine kinase regulation of cardiomyocyte hypertrophy. Am J Physiol Heart Circ Physiol 300 H1722 PMID: 21335462

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