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Ac4ManNAz

Cat. No. 7479 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Azide-containing monosaccharide building block; used as glycoprotein, glycolipid and glycoRNA probe
化学名： 2-[(2-Azidoacetyl)amino]-2-deoxy-D-mannopyranose-1,3,4,6-tetraacetate
纯度： ≥95% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ac4ManNAz

Ac4ManNAz is a cell-permeable, unnatural azide-containing monosaccharide building block. Ac4ManNAz is metabolized and incorporated as azidosialic acid into cell surface and secreted sialoglycoproteins to allow Cu(I)-free click chemistry for further conjugation or detection. Ac4ManNAz can be used for bioorthogonal labeling of human prostate tissue slice cultures; the target sialoglycoproteins can be biotinylated for proteomic analysis or reacted with a cyclooctyne-functionalized optical probe for imaging. Ac4ManNAz is also used to label glycoRNAs on the cell surface.

技术数据 for Ac4ManNAz

分子量 430.37
公式 C16H22N4O10
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 361154-30-5
PubChem ID 71311757
InChI Key HGMISDAXLUIXKM-LIADDWGISA-N
Smiles CC(OC[C@H]1OC([C@H]([C@H]([C@@H]1OC(C)=O)OC(C)=O)NC(CN=[N+]=[N-])=O)OC(C)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ac4ManNAz

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 43.04 100

制备储备液 for Ac4ManNAz

以下数据基于产品分子量 430.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.62 mL 23.24 mL
5 mM 0.46 mL 2.32 mL 4.65 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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参考文献 for Ac4ManNAz

参考文献是支持产品生物活性的出版物。

Spiciarich et al (2017) Bioorthogonal labeling of human prostate cancer tissue slice cultures for glycoproteomics. Angew.Chem.Int.Ed.Engl. 56 8992 PMID: 28649697

Shajahan et al (2017) Carbohydrate-neuroactive hybrid strategy for metabolic glycan engineering of the central nervous system in vivo. J.Am.Chem.Soc. 139 693 PMID: 27997162

Flynn et al (2021) Small RNAs are modified with N-glycans and displayed on the surface of living cells. Cell 184 3109 PMID: 34004145

Zhu et al (2021) Coupling aptamer-based protein tagging with metabolic glycan labeling for in situ visualization and biological function study of exosomal protein-specific glycosylation. Angew.Chem.Int.Ed.Engl. 60 18111 PMID: 34043264

If you know of a relevant reference for Ac4ManNAz, please let us know.

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关键词: Ac4ManNAz, Ac4ManNAz supplier, Ac4ManNAz, cell, permeable, unnatural, azide-containing, monosaccharides, azidosialic, acid, Cu(I)-free, Click, Chemistry, conjugation, detection, glycoproteins, glycolipids, glycoRNA, probes, glycoconjugates, Post-translational, Modifications, Biochemicals, and, Molecular, Biology, Glycobiology, Probes, 7479, Tocris Bioscience

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